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Head-to-head evidence comparison — which supplement is right for you?
Chlorella vs Saccharomyces Boulardii: they're closely matched on evidence (6.5 vs 8.5/10); they're alternatives for support immune system — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Chlorella and Saccharomyces Boulardii are closely matched across evidence, studies, and safety.
Verdict
Too few graded studies
Top outcomes
Verdict
Likely helps
4 of 4 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Chlorella and Saccharomyces Boulardii have evidence — compare verdict strength side-by-side.
3-10g daily
Before meals for detox, With food if GI sensitive, Away from medications (may bind)
Broken cell wall chlorella powder or tablets
250-500mg (5-10 billion CFU) daily
With or without food, At least 2 hours away from antifungals
Capsules (lyophilized)
4-8 weeks
4-8 weeks
8-12 weeks
First 1-2 weeks
During use
1-3 days
1-2 weeks
Identifying immunostimulatory herbal supplements that may flare autoimmune skin diseases: a systematic scoping review
Lupus science & medicine (2025) · Review
Scoping review screening 11,819 articles, of which 469 studies met inclusion criteria, identified 227 herbal supplements with immunostimulatory properties.
Effect of supplementation with Chlorella vulgaris on lipid profile in adults: A systematic review and dose-response meta-analysis of randomized controlled trials
Complementary therapies in medicine (2022) · Meta analysis · n=539
Meta-analysis of 10 RCTs with 539 adults (264 given Chlorella vulgaris, 275 controls).
Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis
Nutrients (2020) · Systematic review
It is estimated to have a worldwide prevalence of 1.78%, with a predominance in females.
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis
Frontiers in cellular and infection microbiology (2025) · Meta analysis · n=5036
Meta-analysis of 19 studies with 5,036 people with H. pylori infection, adding S. boulardii to standard eradication therapy.
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Gut microbes (2024) · Meta analysis · n=2871
This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut.
At 1.5 g a day for 8 weeks, a double-blind trial in 84 adults with type 2 diabetes found no change in blood lipids (PMID 33532874). At 5 g a day for 4 weeks, two double-blind trials found an effect: in 63 mildly hypercholesterolaemic adults total cholesterol changed -1.6% versus 0.03% on placebo (PMID 24920270), and in 34 adults eating three eggs a day LDL-C rose 1.7% versus 14.3% on placebo (PMID 27177615). At 15 g a day for 14 days, total and LDL cholesterol fell in 80 healthy adults (PMID 37049486), but uric acid rose and iron and selenium status fell. The meta-analyses disagree on dose: one found reductions at doses above 4 g a day (PMID 29037431), another found the LDL-C reduction at doses up to 1,500 mg and not above (PMID 35331862). No trial compared doses, so the curve is flat above 5 g and no minimum, optimal or safe ceiling is set.
Both points come from a meta-analysis of 10 randomised trials adding S. boulardii to bismuth quadruple therapy (PMID 40251486), whose dose subgroups found the same gain in eradication at 500 mg a day (RR 1.10, 95% CI 1.03 to 1.17) and 1000 mg a day (RR 1.08, 95% CI 1.03 to 1.12). Effectiveness is the relative gain in eradication in percent. Total adverse effects fell with S. boulardii (RR 0.53), so the side effect values are low. The authors recommend 500 mg a day for more than 10 days. The effect is as an add-on to antibiotics only, and doses are in mg of product, not CFU.
AI-estimated from published studies. Interpret as directional guidance.
Both Chlorella and Saccharomyces Boulardii are closely matched — the best choice depends on your specific health goals.
Both Chlorella and Saccharomyces Boulardii score equally (60) for support immune system.
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.