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Head-to-head evidence comparison — which supplement is right for you?
Clomiphene (Clomid) vs HCG (Human Chorionic Gonadotropin): HCG (Human Chorionic Gonadotropin) has the stronger overall evidence (5.5 vs 4.8/10); they're alternatives for fertility support — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
HCG (Human Chorionic Gonadotropin) wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (2)
Outcomes where both Clomiphene (Clomid) and HCG (Human Chorionic Gonadotropin) have evidence — compare verdict strength side-by-side.
Off-label (male) / approved (female) — clinician-directed. For female ovulation induction the approved regimen is 50 mg once daily for 5 days starting early in the cycle, titrated up to 100-150 mg if needed. For off-label male hypogonadism, observational studies used roughly 25-50 mg daily or every other day (25 mg/day is the most common starting dose), titrated to testosterone and LH/FSH response. There is no FDA-approved male dose.
any
Clomiphene citrate tablets (racemic — approved for women; off-label in men)
Prescription-only and indication-dependent. For fertility preservation / intratesticular-testosterone maintenance on TRT, small studies used ~125-500 IU subcutaneously every other day. For spermatogenesis induction in hypogonadotropic hypogonadism, typically ~1,000-2,500 IU two to three times weekly (often combined with FSH), titrated to response. For female ovulation/oocyte-maturation trigger, a single dose (~5,000-10,000 IU urinary or 250 µg recombinant). No dietary-supplement dose exists.
any
Prescription hCG — recombinant (choriogonadotropin alfa) or urinary-derived, by injection
and 1 more not shown
Per cycle (5-10 day course)
Weeks to a few months
Within 3-6 months
N/A
Weeks
Months
Months
Within ~36 hours
Clomiphene citrate for men with hypogonadism: a systematic review and meta-analysis.
Andrology (2022) · Meta analysis · n=1642
Systematic review and meta-analysis of clomiphene citrate for male hypogonadism — 19 studies (4 RCTs, 15 observational), 1,642 patients; 17 studies (1,279 patients) in the meta-analysis
Letrozole versus clomiphene for infertility in the polycystic ovary syndrome.
N Engl J Med (2014) · Rct · n=750
Double-blind, multicenter RCT (NCT00719186) of 750 women with PCOS randomized 1:1 to letrozole vs clomiphene for up to five cycles; primary outcome live birth
Clomiphene and other antioestrogens for ovulation induction in polycystic ovarian syndrome.
Cochrane Database Syst Rev (2016) · Systematic review
Cochrane systematic review of clomiphene and other antioestrogens for ovulation induction in anovulatory PCOS subfertility
Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression.
J Clin Endocrinol Metab (2005) · Rct · n=29
29 men with normal reproductive physiology randomized to weekly testosterone enanthate plus saline placebo or 125, 250, or 500 IU hCG every other day for 3 weeks
Concomitant intramuscular human chorionic gonadotropin preserves spermatogenesis in men undergoing testosterone replacement therapy.
J Urol (2013) · Observational · n=26
Retrospective cohort of 26 hypogonadal men on testosterone replacement plus 500 IU intramuscular hCG every other day, mean follow-up 6.2 months
A combined analysis of data to identify predictive factors for spermatogenesis in men with hypogonadotropic hypogonadism treated with recombinant human follicle-stimulating hormone and human chorionic gonadotropin.
Fertil Steril (2009) · Observational · n=100
Combined analysis of four Phase III open-label studies in 100 men with complete idiopathic or acquired hypogonadotropic hypogonadism, pretreated with hCG for 3-6 months then hCG plus recombinant FSH
HCG (Human Chorionic Gonadotropin) has a higher evidence score (5.5/10 vs 4.8/10) and wins in 2 of 3 categories.
For fertility support, Clomiphene (Clomid) has a higher relevance score (64 vs 62).
No known interactions between Clomiphene (Clomid) and HCG (Human Chorionic Gonadotropin) have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.