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Head-to-head evidence comparison — which supplement is right for you?
Collagen wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
6 of 6 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mostly mechanism / observational
1 of 1 studies with measurable effects showed benefit.
Top outcomes
10-15g
Any time of day, With vitamin C for enhanced synthesis
Hydrolyzed collagen peptides (powder)
380-760mg, 2-4 times daily
Before meals, Chewable tablets for reflux
Chewable tablets (for GERD/reflux)
8-12 weeks
8-12 weeks
12 weeks
First week
1-4 weeks
1-2 weeks
Effects of Collagen Supplements on Skin Aging: A Systematic Review and Meta-Analysis
The American Journal of Medicine (2025) · Meta analysis · n=1474
23 RCTs with 1474 participants
Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trials
Clinical and experimental rheumatology (2025) · Meta analysis · n=870
The meta-analysis revealed an overall significant improvement of both function [MD, -6.46 (95% CI -9.52, -3.40); I2=75%; p=0.00001] and pain scores [MD, -13.63 (95% CI -20.67, -6.58); I2=88%; p=0.00001], favouring collagen supplementation.
Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous Remodeling, Functional Recovery, and Body Composition in Healthy Adults: A Systematic Review with Meta-analysis
Sports medicine (Auckland, N.Z.) (2024) · Meta analysis · n=768
This systematic review and meta-analysis represents the first comprehensive investigation into the effects of long-term CP supplementation combined with regular physical training on various aspects of musculoskeletal health in adults.
Licorice Root Extract and Its Anti-Helicobacter pylori Properties: A Systematic Review
World Journal of Gastroenterology (2022) · Systematic review · n=520
Licorice extract boosted H. pylori eradication rates when added to standard therapy
Glycyrrhiza glabra (Licorice) in Gastrointestinal Disorders: A Systematic Review of Clinical Evidence
Phytotherapy Research (2021) · Systematic review · n=980
DGL accelerated ulcer healing in gastric and duodenal ulcer patients
Licorice extract for functional dyspepsia
Evidence-Based Complementary and Alternative Medicine (2012) · Rct · n=50
Reduced dyspepsia symptoms
Meta-analysis of 23 RCTs (n=1474) showed high-quality studies had less effect than industry-funded studies. Benefits include improved skin elasticity and hydration. Hydrolyzed collagen peptides preferred for bioavailability.
Based on limited RCT evidence (n=50) and systematic review findings. DGL form preferred to avoid aldosterone effects. Effectiveness estimates conservative given small study sizes.
AI-estimated from published studies. Interpret as directional guidance.
Collagen has a higher evidence score (9/10 vs 6/10) and wins in 2 of 3 categories.
For reduce inflammation, DGL Licorice has a higher relevance score (85 vs 80).
No known interactions between Collagen and DGL Licorice have been documented in our database. However, always consult a healthcare provider before combining supplements.