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Head-to-head evidence comparison — which supplement is right for you?
CoQ10 vs Horse Chestnut: CoQ10 has the stronger overall evidence (8 vs 7/10); they're alternatives for inflammation-related symptoms — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
CoQ10 wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
9 of 10 studies with measurable effects showed benefit.
Top outcomes
Verdict
Too few graded studies
Top outcomes
100-300mg daily
With fatty meal
Ubiquinol (reduced form)
300mg standardized extract twice daily (providing ~50mg aescin per dose; ~100mg aescin/day). A typical label dose, no cited trial of oral horse chestnut states its dose.
With meals
Aescin-standardized, enteric-coated seed extract
4-12 weeks
8-12 weeks
4-8 weeks
2-8 weeks
2-12 weeks
2-8 weeks
Days
Efficacy and Safety of Coenzyme Q10 Supplementation in the Treatment of Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis
Reproductive sciences (Thousand Oaks, Calif.) (2023) · Meta analysis · n=1021
Meta-analysis of 9 randomised trials with 1,021 women with polycystic ovary syndrome.
Coenzyme Q10 for heart failure
The Cochrane database of systematic reviews (2021) · Meta analysis · n=1573
Coenzyme Q10 probably reduces the risk of all-cause mortality more than control (RR 0.58, 95% CI 0.35 to 0.95; 1 study, 420 participants; number needed to treat for an additional beneficial outcome (NNTB) 13.3; moderate-quality evidence).
Antioxidants for female subfertility
The Cochrane database of systematic reviews (2017) · Meta analysis · n=6510
This suggests that among subfertile women with an expected clinical pregnancy rate of 22%, the rate among women using antioxidants would be between 27% and 33%.
Horse chestnut seed extract for chronic venous insufficiency.
The Cochrane database of systematic reviews (2012) · Meta analysis
Significantly reduced leg pain, edema, and itching vs placebo
Horse-chestnut seed extract for chronic venous insufficiency. A criteria-based systematic review.
Archives of dermatology (1998) · Systematic review
Most RCTs favored HCSE over placebo
Aescin: microcirculatory activity. Effects of accessory components on clinical and microcirculatory efficacy.
Panminerva medica (2011) · Open label
Improved microcirculatory parameters
CoQ10 has a higher evidence score (8/10 vs 7/10) and wins in 3 of 3 categories.
For inflammation-related symptoms, CoQ10 has a higher relevance score (75 vs 30).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
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Magnesium, riboflavin, CoQ10 — the supplements with real migraine-prevention evidence (and doses).
CoQ10, zinc, selenium, carnitine modestly help sperm parameters — but live-birth evidence is weak.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.