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Head-to-head evidence comparison — which supplement is right for you?
Digestive Enzymes and Peppermint Oil are closely matched across evidence, studies, and safety.
Verdict
Likely helps
5 of 5 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (1)
Outcomes where both Digestive Enzymes and Peppermint Oil have evidence — compare verdict strength side-by-side.
1-2 capsules with meals (varies by product)
At beginning of meals or just before eating
Broad-spectrum enzyme blend capsules
180-225mg enteric-coated peppermint oil, 2-3 times daily before meals
before-meals
Enteric-coated capsules
Immediate
Immediate
Immediate
Within hours to 4 weeks
Days to weeks
Soon after dosing
Efficacy of pancreatic enzyme replacement therapy in chronic pancreatitis: systematic review and meta-analysis
Gut (2017) · Meta analysis · n=511
PERT improved CFA compared with baseline (83.7±6.0 vs 63.1±15.0, p<0.00001; I2=89%) and placebo (83.2±5.5 vs 67.4±7.0, p=0.0001; I2=86%).
Complementary and Alternative Medicine for Autism - A Systematic Review
Journal of autism and developmental disorders (2025) · Systematic review · n=39
The results of this systematic review identified that for autistic people, vitamin and mineral supplements may only be of benefit if there is a deficiency.
Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder-A Randomized, Controlled 12-Month Trial
Nutrients (2018) · Rct · n=67
There was a significant improvement in nonverbal intellectual ability in the treatment group compared to the non-treatment group (+6.7 ± 11 IQ points vs. -0.6 ± 11 IQ points, p = 0.009) based on a blinded clinical assessment.
The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data.
BMC Complement Altern Med (2019) · Meta analysis · n=835
12 randomized trials, 835 patients pooled
Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis.
J Clin Gastroenterol (2014) · Meta analysis · n=726
9 randomized placebo-controlled trials, 726 patients
Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.
Complement Ther Med (2020) · Meta analysis
33 double-blind placebo-controlled trials reviewed; 17 evaluated peppermint oil
Both Digestive Enzymes and Peppermint Oil are closely matched — the best choice depends on your specific health goals.
For improve digestion, Digestive Enzymes has a higher relevance score (95 vs 85).
No known interactions between Digestive Enzymes and Peppermint Oil have been documented in our database. However, always consult a healthcare provider before combining supplements.