Loading…
We use essential cookies (authentication, your saved goals/stack) by default. With your permission we'll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Head-to-head evidence comparison — which supplement is right for you?
Vitamin B12 wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Probably helps
16 of 23 studies with measurable effects showed benefit.
Top outcomes
180-225mg enteric-coated peppermint oil, 2-3 times daily before meals
before-meals
Enteric-coated capsules
500-1000mcg daily for maintenance; higher for deficiency
Morning (may be energizing), With or without food
Methylcobalamin (sublingual)
Within hours to 4 weeks
Days to weeks
Soon after dosing
2-4 weeks
4-8 weeks
Weeks to months
The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data.
BMC Complement Altern Med (2019) · Meta analysis · n=835
12 randomized trials, 835 patients pooled
Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis.
J Clin Gastroenterol (2014) · Meta analysis · n=726
9 randomized placebo-controlled trials, 726 patients
Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.
Complement Ther Med (2020) · Meta analysis
33 double-blind placebo-controlled trials reviewed; 17 evaluated peppermint oil
Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Irish journal of medical science (2024) · Meta analysis · n=4275
Regarding the hemoglobin level, the pooled effect sizes showed no difference between all routes of administration that could reach statistical significance.
Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review
The American journal of clinical nutrition (2024) · Meta analysis · n=76664
In areas without and with partial folic acid fortification, combined B-vitamin supplementation significantly reduced the risk of stroke by 34% [RR: 0.66; 95% confidence interval (CI): 0.50, 0.86] and 11% (RR: 0.89; 95% CI: 0.79, 1.00), respectively.
Vitamin Status in Patients with Phenylketonuria: A Systematic Review and Meta-Analysis
International journal of molecular sciences (2024) · Meta analysis · n=770
The effect sizes were expressed as standardised mean differences.
Vitamin B12 has a higher evidence score (7.5/10 vs 7/10) and wins in 2 of 3 categories.
No known interactions between Peppermint Oil and Vitamin B12 have been documented in our database. However, always consult a healthcare provider before combining supplements.