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Head-to-head evidence comparison — which supplement is right for you?
Tretinoin (Retin-A) wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
1000mg MPFF daily (900mg diosmin + 100mg hesperidin); acute hemorrhoid protocols use higher short-term doses
with-meals
MPFF (micronized diosmin + hesperidin)
Prescription topical: a pea-sized amount of 0.025%-0.1% cream or gel applied to clean, dry skin once nightly. Start low-strength and every-other-night to build tolerance. A prescription drug used under clinician direction — not a supplement regimen.
before-bed
Topical cream or gel, 0.025%-0.1% (prescription)
2-8 weeks
2-8 weeks
Days-weeks
12-24 weeks
12-24 weeks
Months
8-12 weeks
Efficacy of micronized purified flavonoid fraction (Daflon(R)) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials.
Int Angiol (2018) · Meta analysis
MPFF improved leg symptoms, edema, and quality of life in chronic venous disease
Phlebotonics for venous insufficiency.
Cochrane Database Syst Rev (2020) · Meta analysis
Cochrane: phlebotonics probably reduce edema (moderate-certainty evidence)
Phlebotonics for haemorrhoids.
Cochrane Database Syst Rev (2012) · Meta analysis
Phlebotonics improved hemorrhoid symptoms (bleeding, itching, discharge)
Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study.
JAMA (1988) · Rct
Randomized, double-blind, vehicle-controlled trial of topical tretinoin for photoaged forearm and facial skin
Tretinoin emollient cream: a new therapy for photodamaged skin.
J Am Acad Dermatol (1992) · Rct
Multicenter double-blind vehicle-controlled trial of tretinoin emollient cream for photodamaged skin
Long-term treatment of photoaged human skin with topical retinoic acid improves epidermal cell atypia and thickens the collagen band in papillary dermis.
J Am Acad Dermatol (2005) · Open label
Long-term topical retinoic acid on photoaged human skin assessed histologically
Tretinoin (Retin-A) has a higher evidence score (8/10 vs 7/10) and wins in 2 of 3 categories.
No known interactions between Diosmin and Tretinoin (Retin-A) have been documented in our database. However, always consult a healthcare provider before combining supplements.