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Head-to-head evidence comparison — which supplement is right for you?
Dutasteride vs Pygeum: Pygeum has the stronger overall evidence (5.5 vs 5.4/10); they're alternatives for prostate health — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Pygeum wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Likely helps
3 of 3 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (2)
Outcomes where both Dutasteride and Pygeum have evidence — compare verdict strength side-by-side.
Approved BPH dose is 0.5 mg once daily; off-label hair-loss use mirrors the same 0.5 mg once-daily dose under a clinician. A prescription drug.
anytime
Oral soft-gel capsule (dutasteride 0.5 mg)
100-200mg standardized extract daily
Once or twice daily, With or without food
Standardized extract (13-14% sterols)
3–6 months
Months
Years
Weeks; may persist
6-8 weeks
6-8 weeks
8-12 weeks
The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride.
Journal of the American Academy of Dermatology (2006) · Rct · n=416
Randomized placebo-controlled trial of 416 men comparing dutasteride doses, finasteride 5 mg, and placebo over 24 weeks
Efficacy, safety, and tolerability of dutasteride 0.5 mg once daily in male patients with male pattern hair loss: a randomized, double-blind, placebo-controlled, phase III study.
Journal of the American Academy of Dermatology (2010) · Rct · n=153
Phase-III randomized double-blind placebo-controlled trial of 153 men over 6 months
The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4-year results from the CombAT study.
European urology (2010) · Rct · n=4844
CombAT: 4-year multicenter randomized double-blind trial in 4844 men with symptomatic BPH and prostatic enlargement
What do we know about phytotherapy of benign prostatic hyperplasia?
Life sciences (2015) · Systematic review
On the basis of preclinical studies several mechanisms of action have been postulated, including 5alpha-reductase inhibition, alpha-adrenergic antagonism, dihydrotestosterone and estrogen receptor inhibition.
Phytotherapy of benign prostatic hyperplasia. A minireview
Phytotherapy research : PTR (2014) · Systematic review
Histological BPH, which typically develops after the age of 40 years, ranges in prevalence from >50% at 60 years to as high as 90% by 85 years of age.
Benign prostatic hyperplasia and male lower urinary tract symptoms (LUTS)
BMJ clinical evidence (2011) · Systematic review
We found 63 systematic reviews, RCTs, or observational studies that met our inclusion criteria.
Based on Cochrane review (n=1562) and network meta-analysis showing modest benefits. Evidence quality noted as low-to-moderate due to dated methodology in available RCTs. Most studies used standardized bark extract.
AI-estimated from published studies. Interpret as directional guidance.
Pygeum has a higher evidence score (5.5/10 vs 5.4/10) and wins in 3 of 3 categories.
For prostate health, Pygeum has a higher relevance score (80 vs 75).
No known interactions between Dutasteride and Pygeum have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.