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Head-to-head evidence comparison — which supplement is right for you?
Ginkgo Biloba vs Tirzepatide: Ginkgo Biloba has the stronger overall evidence (7 vs 7.8/10); the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Ginkgo Biloba wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
5 of 8 studies with measurable effects showed benefit.
Top outcomes
Verdict
Too few graded studies
Top outcomes
120-240mg standardized extract
With meals, Split into 2-3 doses
Standardized extract capsules (EGb 761)
Once-weekly subcutaneous injection, started at 2.5 mg and escalated by 2.5 mg every 4 weeks to a maintenance dose of 5, 10, or 15 mg (per the prescribing physician and approved indication)
Any time of day
Once-weekly subcutaneous injection (Mounjaro / Zepbound)
12-24 weeks
8-12 weeks
First week
Weeks to months
Months (dose-escalated over ~20 weeks)
Weeks to months
Mostly during titration
Can We Use Ginkgo biloba Extract to Treat Alzheimer's Disease? Lessons from Preclinical and Clinical Studies
Cells (2022) · Meta analysis · n=2100
GBE was shown to reduce the escape latencies in several studies, in both rats and mice (I2 > 70%, p < 0.005).
Beneficial effects of Ginkgo biloba leaf extract on inflammatory markers: A systematic review and meta-analysis of the clinical trials
Phytotherapy research : PTR (2022) · Meta analysis · n=1104
In the meta-analysis, the weighted mean differences (WMD) in change for serum CRP were -1.5 mg/L (95% CI: -2.16, -0.85, p < 0.001).
Miscellaneous treatments for antipsychotic-induced tardive dyskinesia
The Cochrane database of systematic reviews (2018) · Meta analysis · n=1278
Studies were primarily of short (three to six6 weeks) duration with small samples size (10 to 157 participants), and most (61%) were published more than 20 years ago.
Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes.
N Engl J Med (2021) · Rct · n=1879
Open-label 40-week phase-3 head-to-head RCT (SURPASS-2) in 1879 patients with type 2 diabetes, tirzepatide 5/10/15 mg vs semaglutide 1 mg
Tirzepatide Once Weekly for the Treatment of Obesity.
N Engl J Med (2022) · Rct · n=2539
72-week phase-3 double-blind RCT (SURMOUNT-1) in 2539 adults with obesity (without diabetes), tirzepatide 5/10/15 mg vs placebo
Tirzepatide as Compared with Semaglutide for the Treatment of Obesity.
N Engl J Med (2025) · Rct · n=751
Phase-3b open-label head-to-head RCT (SURMOUNT-5) in 751 adults with obesity but without diabetes, max-tolerated tirzepatide vs max-tolerated semaglutide
The trials behind these points gave 120 or 240 mg of the standardised extract EGb 761 daily to people with dementia for about 6 months (PMID 25506211, 7 trials, 2,625 patients). A meta-analysis of 9 trials found the benefits on cognition, daily activities and global impression mainly at 240 mg (PMID 25114079), and one of mild dementia subgroups found medium to large effects at 240 mg (PMID 39895346). A network meta-analysis of trials lasting over a year ranked 120 mg best for cognition in Alzheimer's disease (PMID 39312316), so 120 mg is plotted as effective, not null. Adverse events matched placebo at both doses. The Cochrane review rates the dementia benefit small to moderate and low certainty, and found little or no effect in mild cognitive impairment (PMID 41641880). In older people with normal cognition, 240 mg a day for about 6 years did not prevent dementia (PMID 19017911). No cited trial tested more than 240 mg.
AI-estimated from published studies. Interpret as directional guidance.
Ginkgo Biloba has a higher evidence score (7/10 vs 7.8/10) and wins in 2 of 3 categories.
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.