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Head-to-head evidence comparison — which supplement is right for you?
Glucomannan vs Urolithin A: Glucomannan has the stronger overall evidence (6.5 vs 6/10); they're alternatives for boost daily energy — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Glucomannan wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
7 of 8 studies with measurable effects showed benefit.
Top outcomes
Verdict
Too few graded studies
1 of 1 studies with measurable effects showed benefit.
Top outcomes
1g three times daily before meals (3g total)
30-60 minutes before meals, With 1-2 glasses of water, Before largest meals for weight loss
Capsules (safest)
500-1000mg
Morning with food
Mitopure (highly pure, bioavailable form)
30-60 minutes
4-8 weeks
4-8 weeks
If improperly taken
4-8 weeks
8-16 weeks
8-16 weeks
Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis
The American journal of clinical nutrition (2008) · Meta analysis · n=531
Meta-analysis of 14 randomised controlled trials with 531 participants.
The Impact of Glucomannan, Inulin, and Psyllium Supplementation (Soloways(TM)) on Weight Loss in Adults with FTO, LEP, LEPR, and MC4R Polymorphisms: A Randomized, Double-Blind, Placebo-Controlled Trial
Nutrients (2024) · Rct · n=112
The experimental group showed significant reductions in body weight (treatment difference: -4.9%; 95% CI: -6.9% to -2.9%; p < 0.01) and BMI (treatment difference: -1.4 kg/m2; 95% CI: -1.7 to -1.2; p < 0.01) compared to placebo.
Comparative effects of nutraceuticals on body weight in adults with overweight or obesity: A systematic review and network meta-analysis of 111 randomized clinical trials
Pharmacological research (2023) · Meta analysis · n=6171
We conducted random-effects network meta-analysis with a Frequentist framework to estimate mean difference [MD] and 95% confidence interval [CI] of the effect of nutraceuticals on weight loss.
The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)
The American journal of clinical nutrition (2022) · Rct · n=284
Among 284 participants (88% men; mean age: 51 y; BMI: 31.2 kg/m2; APOE-ε4 genotype = 15.7%), 224 (79%) completed the trial with eligible whole-brain MRIs.
Urolithin A induces mitophagy and prolongs lifespan
Nature Medicine (2016) · Preclinical
Extended lifespan in animal models
Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial
Nature aging (2025) · Rct · n=50
Exploratory single-cell RNA sequencing demonstrated UA-driven transcriptional shifts across immune populations, modulating pathways linked to inflammation and metabolism.
Two trials of glucomannan on its own report both a dose and a weight outcome. In a single-blind, placebo-controlled crossover of 20 adults with type 2 diabetes, 3 g a day for 4 weeks lowered BMI, a secondary result (PMID 18041436). In a randomised placebo-controlled trial of 53 overweight or moderately obese adults, 1.33 g before each of three meals (about 4 g a day) for 8 weeks did not change weight compared with placebo, and gastrointestinal symptoms, liver enzymes and creatinine did not differ from placebo (PMID 24490058). The curve stays flat at 4 g for that reason. No trial compared doses. The weight meta-analyses cited here do not state a dose, so they are not plotted.
Both doses come from the first-in-human trial in healthy sedentary older adults (PMID 32694802), where 4 weeks of 500 mg or 1,000 mg modulated plasma acylcarnitines and muscle mitochondrial gene expression, with a favourable safety profile at every dose tested. The abstract does not rank the two doses, so the curve is flat. A 4-month trial of 1,000 mg in 66 adults aged 65 to 90 (PMID 35050355) also lowered acylcarnitines and C-reactive protein, but found no gain in maximal ATP production, a direct measure of mitochondrial function. These are biomarkers, not clinical outcomes, and no dose above 1,000 mg was tested.
AI-estimated from published studies. Interpret as directional guidance.
Glucomannan has a higher evidence score (6.5/10 vs 6/10) and wins in 2 of 3 categories.
For boost daily energy, Glucomannan has a higher relevance score (80 vs 75).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.