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Head-to-head evidence comparison — which supplement is right for you?
Aged Garlic Extract vs Glucomannan: Aged Garlic Extract has the stronger overall evidence (7.5 vs 6.5/10); they're alternatives for inflammation-related symptoms — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Aged Garlic Extract wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
11 of 12 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
12 of 13 studies with measurable effects showed benefit.
Top outcomes
600-960mg aged garlic extract — range pending qualified review, and not scoped to a formulation, population, duration or outcome
With meals, Split into 2 doses
Kyolic Aged Garlic Extract (most studied)
1g three times daily before meals (3g total)
30-60 minutes before meals, With 1-2 glasses of water, Before largest meals for weight loss
Capsules (safest)
8-12 weeks
12+ weeks
4-8 weeks
30-60 minutes
4-8 weeks
4-8 weeks
If improperly taken
Effect of garlic extract on markers of lipid metabolism and inflammation in coronary artery disease (CAD) patients: A systematic review and meta-analysis
Phytotherapy research : PTR (2023) · Meta analysis
The standardized mean difference with 95% CI was calculated using fixed-effect or random-effect models.
A meta-analysis of randomized, double-blind, placebo-controlled trials for the effects of garlic on serum lipid profiles
Journal of the science of food and agriculture (2012) · Meta analysis · n=26
Compared with the placebo groups, serum TC and TG levels in the garlic group were reduced by 0.28 (95% CI, -0.45, -0.11) mmol L⁻¹ (P = 0.001) and 0.13 (95% CI, -0.20, -0.06) mmol L⁻¹ (P < 0.001), respectively.
A randomized factorial study of the effects of long-term garlic and micronutrient supplementation and of 2-wk antibiotic treatment for Helicobacter pylori infection on serum cholesterol and lipoproteins
The American journal of clinical nutrition (2006) · Rct · n=3411
Regressions adjusted for covariates indicated increases of 0.22 mmol total cholesterol/L (P = 0.01) and 0.19 mmol LDL/L (P = 0.02) after 7.3 y of micronutrient supplementation, but no effect of garlic supplementation or short-term amoxicillin and omeprazole treatment.
Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis
The American journal of clinical nutrition (2008) · Meta analysis · n=531
Glucomannan appears to beneficially affect total cholesterol, LDL cholesterol, triglycerides, body weight, and FBG, but not HDL cholesterol or BP.
The Impact of Glucomannan, Inulin, and Psyllium Supplementation (Soloways(TM)) on Weight Loss in Adults with FTO, LEP, LEPR, and MC4R Polymorphisms: A Randomized, Double-Blind, Placebo-Controlled Trial
Nutrients (2024) · Rct · n=112
The experimental group showed significant reductions in body weight (treatment difference: -4.9%; 95% CI: -6.9% to -2.9%; p < 0.01) and BMI (treatment difference: -1.4 kg/m2; 95% CI: -1.7 to -1.2; p < 0.01) compared to placebo.
Comparative effects of nutraceuticals on body weight in adults with overweight or obesity: A systematic review and network meta-analysis of 111 randomized clinical trials
Pharmacological research (2023) · Meta analysis · n=6171
We conducted random-effects network meta-analysis with a Frequentist framework to estimate mean difference [MD] and 95% confidence interval [CI] of the effect of nutraceuticals on weight loss.
Retraction repair (2026-09-03). Everything this curve asserted above the studied range came from the 2024 meta-analysis that has since been retracted (PMID 39437887): its subgroup claim of a benefit threshold ABOVE every dose the surviving trials tested was the sole support for this curve's three highest points and for its former optimum, so those points and that optimum are removed rather than re-estimated, and the claim is not repeated here. NO OPTIMAL DOSE IS ASSERTED IN ITS PLACE. The only randomised dose COMPARISON left in this entry runs the other way: Ried 2013 (n=79), a dose-response trial, found 480 mg/day lowered systolic pressure by 11.8 mmHg (p=0.006) while its own 960 mg/day arm reached only 7.4 mmHg (p=0.07), with tolerability best at the one- and two-capsule doses. Ried 2010 (n=50) found 10.2 mmHg at 960 mg/day, but that is a different trial, not evidence that 960 beats 480. A 2023 triple-blind trial added on top of drug therapy found about 2 mmHg. So the remaining evidence does not describe a dose-response shape at all, and the sweet-spot marker stays off the chart until a clinician rules on it. minimumEffectiveDose 480 is the lowest dose at which a randomised arm in this entry showed a significant reduction; it is a cited dose, not a shape. No maxSafeDose is asserted on this curve: the field is null. ⚠️ An earlier version of this note described a stored 2400 as "unverified and left in place" — that value was removed on 2026-09-06 and the sentence outlived it, so a reader was told about a ceiling that no longer existed. The account of why no ceiling is stated lives in safety.maxSafeDose and is not repeated here. Confidence is downgraded to low: no pooled estimate survives.
Meta-analysis of 6 RCTs (n=225) showed modest but significant weight reduction vs placebo. Effects appear greater in females. Limited long-term data available.
AI-estimated from published studies. Interpret as directional guidance.
Aged Garlic Extract has a higher evidence score (7.5/10 vs 6.5/10) and wins in 2 of 3 categories.
For inflammation-related symptoms, Aged Garlic Extract has a higher relevance score (90 vs 65).
No known interactions between Aged Garlic Extract and Glucomannan have been documented in our database. However, always consult a healthcare provider before combining supplements.
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Zinc timing, vitamin D, the real vitamin C effect — and the elderberry caution.
Probiotics vs prebiotics vs synbiotics, the CFU myth, and what actually helps bloating.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.