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Head-to-head evidence comparison — which supplement is right for you?
Glycine wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
6 of 6 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mostly mechanism / observational
1 of 1 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Glycine and Valerian Root have evidence — compare verdict strength side-by-side.
3g before bed
30-60 minutes before bed
Powder (dissolves easily, tastes sweet)
300-600mg extract
30-60 minutes before bed
Standardized extract capsules
First few nights
Next morning
Immediate
2-4 weeks
2-4 weeks
Next morning
Immediate
The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review
GeroScience (2024) · Systematic review · n=34
The nervous system demonstrated the most positive effects, including improved psychiatric symptoms from longer-term glycine administration in psychiatric populations.
Glutamatergic drugs for schizophrenia
The Cochrane database of systematic reviews (2006) · Meta analysis · n=132
NMDA receptor co-agonists glycine and D-serine showed some effects in reducing the negative symptoms of schizophrenia (n=132, SMD -0.66, CI -1.0 to -0.3, p=0.0004), but the magnitude of the effect was moderate.
Ingestion of a Whey Plus Collagen Protein Blend Increases Myofibrillar and Muscle Connective Protein Synthesis Rates
Medicine and science in sports and exercise (2025) · Rct · n=14
In addition, myofibrillar protein synthesis rates were higher in BLEND compared with PLA in both the rested (0.038 ± 0.008 and 0.031 ± 0.006%·h -1 , respectively; P < 0.05) and exercised (0.052 ± 0.011 and 0.039 ± 0.009%·h -1 , respectively; P < 0.01) leg.
Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis
Journal of evidence-based integrative medicine (2020) · Meta analysis · n=6894
In addition, therapeutic benefits could be optimized when it was combined with appropriate herbal partners.
Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trial
Phytotherapy research : PTR (2009) · Rct · n=182
Analysis of the ITT population confirmed these results.
Herbal Medicines in Autism Spectrum Disorder: Therapeutic Potential, Plant Components, and Dosage Guidelines
Alternative therapies in health and medicine (2025) · Systematic review
Passionflower and Valerian Root alleviate anxiety and hyperactivity through GABAergic pathways.
Based on systematic review showing nervous system benefits. Limited specific RCT data for sleep outcomes. Effects may vary significantly between individuals.
Based on meta-analysis (n=1602) showing statistically significant improvement in subjective sleep quality but no improvement in objective polysomnography measures. Effect magnitude is conservative given mixed objective evidence.
AI-estimated from published studies. Interpret as directional guidance.
Glycine has a higher evidence score (6.5/10 vs 5.5/10) and wins in 3 of 3 categories.
For improve deep sleep quality, Glycine has a higher relevance score (95 vs 75).
No known interactions between Glycine and Valerian Root have been documented in our database. However, always consult a healthcare provider before combining supplements.