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Head-to-head evidence comparison — which supplement is right for you?
Goji Berries vs Lutein + Zeaxanthin: Lutein + Zeaxanthin has the stronger overall evidence (7 vs 4.8/10); they're alternatives for protect vision — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Lutein + Zeaxanthin wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Likely helps
17 of 18 studies with measurable effects showed benefit.
Top outcomes
15-45g dried berries daily, or ~150-300mg standardized Lycium barbarum polysaccharide (LBP) extract
any
Dried berries or standardized LBP extract
10mg lutein + 2mg zeaxanthin
With a meal containing fat
Softgels with both lutein and zeaxanthin
8-12 weeks
4-12 weeks
8-12 weeks
3-6 months
4-8 weeks
3-6 months
Cardiovascular disease risk reduction with wolfberry consumption: a systematic review and meta-analysis of randomized controlled trials.
European journal of nutrition (2022) · Meta analysis
Improved cardiovascular risk markers
L. barbarum (Lycium barbarum L.) supplementation for lipid profiles in adults: A systematic review and meta-analysis of RCTs.
Medicine (2023) · Meta analysis
Improvements in lipid markers
A meta-analysis of clinical improvements of general well-being by a standardized Lycium barbarum.
Journal of medicinal food (2012) · Meta analysis
Improved subjective well-being/energy
The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis
The American journal of clinical nutrition (2016) · Meta analysis · n=387569
Meta-analysis showed a lower risk of coronary heart disease (pooled RR: 0.88; 95% CI: 0.80, 0.98) and stroke (pooled RR: 0.82; 95% CI: 0.72, 0.93) for the highest compared with the lowest tertile of lutein blood concentration or intake.
Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration
The Cochrane database of systematic reviews (2023) · Systematic review · n=2445
These studies enroled 11,952 people aged 65 to 75 years and included slightly more women (on average 56% women).
Long-term Outcomes of Adding Lutein/Zeaxanthin and ω-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degeneration Progression: AREDS2 Report 28
JAMA ophthalmology (2022) · Rct · n=3882
This study included 3882 participants (mean [SD] baseline age, 72.0 [7.7] years; 2240 women [57.7%]) and 6351 eyes.
Based on multiple meta-analyses showing significant MPOD increases in both AMD patients and healthy subjects. Effect size modest but consistent across studies. Higher doses may increase carotenodermia risk.
AI-estimated from published studies. Interpret as directional guidance.
Lutein + Zeaxanthin has a higher evidence score (7/10 vs 4.8/10) and wins in 3 of 3 categories.
For protect vision, Lutein + Zeaxanthin has a higher relevance score (85 vs 55).
No known interactions between Goji Berries and Lutein + Zeaxanthin have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.