Head-to-head evidence comparison — which supplement is right for you?
L-Glutamine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
5-10g
Post-workout, Before bed, Or split throughout day
L-Glutamine powder
2-3g
With meals, Split into 2-3 doses
Powder or capsules
2-4 weeks
2-4 weeks
1-2 weeks
4-12 weeks
2-4 weeks
8-12 weeks
Multi-cohort analysis of depression-associated gut bacteria sheds insight on bacterial biomarkers across populations
Cellular and molecular life sciences : CMLS (2022) · Meta analysis · n=1827
By contrast, elevated L-glutamine degradation, and reduced L-glutamate and L-isoleucine biosynthesis were identified in depressive-associated microbiomes.
Metabolomics in Diabetic Retinopathy: A Systematic Review
Investigative ophthalmology & visual science (2021) · Systematic review
This review summarizes potential biomarkers and metabolic pathways, providing insights into new pathogenic pathways for this microvascular complication of diabetes.
L-glutamine supplementation in critically ill patients: A systematic review and meta-analysis
Critical Care Medicine (2020) · Meta analysis · n=4671
Parenteral glutamine reduced infectious complications in ICU patients
Effects of dietary supplements on patients with osteoarthritis: A systematic review and network meta-analysis
Journal of integrative medicine (2025) · Meta analysis · n=2455
In the WOMAC pain score, the SUCRA of passion fruit peel extract was 91% (mean difference [MD]: -9.2; 95% confidence interval [CI]: [-16.0, -2.3]), followed by methylsulfonylmethane (89%), undenatured type II collagen (87%), collagen (84%), and Lanconone (82%).
Doxycycline prophylaxis for the prevention of sexually transmitted infections: A systematic review and meta-analysis of randomized controlled trials
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases (2024) · Meta analysis · n=1766
The pooled analysis of 1,766 participants with 602 newly diagnosed STIs showed a 56% decrease in the overall STI incidence using doxy-PrEP/PEP (RR = 0.44; 95% CI: 0.30-0.65; I2 = 73%).
Effect of screening for Neisseria gonorrhoeae and Chlamydia trachomatis on incidence of these infections in men who have sex with men and transgender women taking HIV pre-exposure prophylaxis (the Gonoscreen study): results from a randomised, multicentre, controlled trial
The lancet. HIV (2024) · Rct · n=506
We failed to show that non-screening for N gonorrhoeae and C trachomatis is non-inferior to 3 × 3 screening in MSM and transgender women taking PrEP in Belgium.
L-Glutamine has a higher evidence score (9/10 vs 8.5/10) and wins in 2 of 3 categories.
For reduce inflammation, L-Glutamine has a higher relevance score (85 vs 80).
No known interactions between L-Glutamine and MSM have been documented in our database. However, always consult a healthcare provider before combining supplements.