Head-to-head evidence comparison — which supplement is right for you?
L-Theanine wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
100-200mg
Morning with coffee for focus, Evening for relaxation, As needed for stress
Suntheanine® capsules or powder
300-600mg extract
As needed for anxiety, 30-60 minutes before bed for sleep
Standardized extract capsules
30-60 minutes
30-60 minutes
30-60 minutes
Varies
30-60 minutes
30-60 minutes
2-4 weeks
The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis
Sleep medicine reviews (2025) · Meta analysis · n=897
The findings indicate the potential use of L-theanine in the management of sleep disturbances; however, the lack of studies on "pure" L-theanine warrants further investigation.
Efficiency of Different Supplements in Alleviating Symptoms of ADHD with or Without the Use of Stimulants: A Systematic Review
Nutrients (2025) · Systematic review
The evidence revealed the potential use of supplements as complementary ADHD treatments under clinical guidance.
The Role of Supplements and Over-the-Counter Products to Improve Sleep in Children: A Systematic Review
International journal of molecular sciences (2023) · Systematic review
Although good sleep quality in children has been proven to be a key factor for optimal cognitive, physical and psychological development, a significant and ever-increasing percentage of the pediatric population suffers from sleep disorders.
Aromatherapy for dementia
The Cochrane database of systematic reviews (2020) · Meta analysis · n=708
We have not found any convincing evidence that aromatherapy (or exposure to fragrant plant oils) is beneficial for people with dementia although there are many limitations to the data.
Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Neuropsychopharmacology reports (2025) · Meta analysis · n=1049
A meta-analysis found no significant difference in response rates between the two treatments (risk ratio [RR] = 0.96, 95% CI: 0.78-1.18) or dropout rates (RR = 1.08, 95% CI: 0.62-1.88).
Interventions for postburn pruritus
The Cochrane database of systematic reviews (2024) · Meta analysis · n=49
Due to very low-certainty evidence, it is uncertain whether doxepin cream impacts the incidence of somnolence as an adverse event compared to oral antihistamine (risk ratio (RR) 0.64, 95% CI 0.32 to 1.25; 1 study, 24 participants).
L-Theanine has a higher evidence score (9/10 vs 8.5/10) and wins in 1 of 3 categories.
For reduce anxiety & stress, L-Theanine has a higher relevance score (85 vs 80).
No known interactions between L-Theanine and Lemon Balm have been documented in our database. However, always consult a healthcare provider before combining supplements.