Loading…
We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Head-to-head evidence comparison — which supplement is right for you?
L. plantarum 299v vs Turkey Tail: Turkey Tail has the stronger overall evidence (6 vs 5/10); they're alternatives for improve digestion — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Turkey Tail wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Mostly mechanism / observational
2 of 2 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both L. plantarum 299v and Turkey Tail have evidence — compare verdict strength side-by-side.
1 x 10^9 CFU (1 billion) daily taken WITH the iron-containing meal is sufficient for the iron effect — in the dual-isotope crossover trial 10^9 was significant (28.6% vs 18.5%, p<0.028) while 10^10 was NOT (29.1% vs 20.1%, p=0.080). The freeze-dried capsule and IBS trials used 1 x 10^10 CFU daily, and the pregnancy trial used 1 x 10^10 CFU twice daily (2 x 10^10 CFU/day)
With meals
Freeze-dried capsule standardized to 299v (DSM 9843)
1-3g dried mushroom or equivalent extract
With or without food
Hot water extract capsules or powder
Immediate, per meal
12-25 weeks
4 weeks
n/a
4-8 weeks
4-8 weeks
A Systematic Review and Meta-Analysis on the Effects of Probiotic Species on Iron Absorption and Iron Status.
Nutrients (2019) · Meta analysis
Pooled SMD 0.55 (95% CI 0.22-0.88, p=0.001) for increased iron absorption across 8 studies
The effect of Lactiplantibacillus plantarum 299v together with a low dose of iron on iron status in healthy pregnant women: A randomized clinical trial.
Acta Obstet Gynecol Scand (2021) · Rct · n=326
Iron deficiency at week 35: 59% vs 78% (p=0.017); iron-deficiency anaemia 7.4% vs 21% (p=0.023)
Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis.
Gastroenterology (2023) · Meta analysis
For global IBS symptoms, certainty of evidence was LOW for this strain (moderate only for Escherichia strains)
Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer
International journal of molecular sciences (2023) · Review
In this article, we reviewed mushrooms showing antineoplastic activity again breast cancer cells, especially focusing on the possible bioactive compounds involved and their mechanisms of action.
Coriolus (Trametes) versicolor mushroom to reduce adverse effects from chemotherapy or radiotherapy in people with colorectal cancer
The Cochrane database of systematic reviews (2022) · Systematic review · n=1569
We found low-certainty evidence of a small effect of adjunctive Coriolus on improved survival at five years compared with no adjunctive care (RR 1.08, 95% CI 1.01 to 1.15; 1094 participants; 3 studies; number needed to benefit (NNTB) = 16 (95% Cl 9 to 70).
Current Advancements in Antitumor Properties and Mechanisms of Medicinal Components in Edible Mushrooms
Nutrients (2022) · Review
Our review summarizes the research progress on the anticancer properties of edible and medicinal fungi and the underlying molecular mechanism, which may offer a better understanding of this field.
The only cited trial that compared doses is a phase I dose-escalation study with no control group (PMID 22701186): women who had finished radiotherapy for breast cancer took 3, 6 or 9 g a day of a Trametes versicolor preparation for 6 weeks, 3 women per dose, 9 completing. It reported trends, not significant effects: higher lymphocyte counts at 6 and 9 g, higher natural killer cell activity at 6 g, and dose-related rises in CD8+ T cells and CD19+ B cells. Nine adverse events were reported (7 mild, 1 moderate, 1 severe) and the authors judged up to 9 g a day safe and tolerable. These are blood immune markers, not infections or other clinical outcomes, and no trial shows a benefit above 6 g.
AI-estimated from published studies. Interpret as directional guidance.
Turkey Tail has a higher evidence score (6/10 vs 5/10) and wins in 2 of 3 categories.
For improve digestion, Turkey Tail has a higher relevance score (52 vs 50).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.