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Head-to-head evidence comparison — which supplement is right for you?
L. rhamnosus GG vs Turkey Tail: L. rhamnosus GG has the stronger overall evidence (6 vs 6/10); they're alternatives for improve digestion — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
L. rhamnosus GG wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
2 of 2 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both L. rhamnosus GG and Turkey Tail have evidence — compare verdict strength side-by-side.
10-20 billion CFU (1-2 x 10^10) daily. A meta-analysis in children with acute gastroenteritis found LGG effective at 10 billion CFU/day or more, and borderline below that.
Any time of day
Capsule standardized to ATCC 53103
1-3g dried mushroom or equivalent extract
With or without food
Hot water extract capsules or powder
During the antibiotic course
During hospital stay
n/a
n/a
4-8 weeks
4-8 weeks
Lactobacillus rhamnosus GG versus Placebo for Acute Gastroenteritis in Children.
N Engl J Med (2018) · Rct · n=971
Primary outcome (modified Vesikari score >=9 within 14 days): 11.8% with LGG vs 12.6% placebo; RR 0.96 (0.68-1.35), P=0.83
Systematic review with meta-analysis: Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea in children and adults.
Aliment Pharmacol Ther (2015) · Meta analysis
Antibiotic-associated diarrhea fell from 22.4% to 12.3%; RR 0.49 (0.29-0.83) pooled across 11 RCTs, n=1,308 (12 RCTs, n=1,499 included overall)
Probiotics for treating acute infectious diarrhoea.
Cochrane Database Syst Rev (2020) · Meta analysis
In studies at low risk of bias, no difference in diarrhea lasting >=48 hours (RR 1.00, 0.91-1.09; moderate certainty)
Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer
International journal of molecular sciences (2023) · Review
In this article, we reviewed mushrooms showing antineoplastic activity again breast cancer cells, especially focusing on the possible bioactive compounds involved and their mechanisms of action.
Coriolus (Trametes) versicolor mushroom to reduce adverse effects from chemotherapy or radiotherapy in people with colorectal cancer
The Cochrane database of systematic reviews (2022) · Systematic review · n=1569
We found low-certainty evidence of a small effect of adjunctive Coriolus on improved survival at five years compared with no adjunctive care (RR 1.08, 95% CI 1.01 to 1.15; 1094 participants; 3 studies; number needed to benefit (NNTB) = 16 (95% Cl 9 to 70).
Current Advancements in Antitumor Properties and Mechanisms of Medicinal Components in Edible Mushrooms
Nutrients (2022) · Review
Our review summarizes the research progress on the anticancer properties of edible and medicinal fungi and the underlying molecular mechanism, which may offer a better understanding of this field.
The only cited trial that compared doses is a phase I dose-escalation study with no control group (PMID 22701186): women who had finished radiotherapy for breast cancer took 3, 6 or 9 g a day of a Trametes versicolor preparation for 6 weeks, 3 women per dose, 9 completing. It reported trends, not significant effects: higher lymphocyte counts at 6 and 9 g, higher natural killer cell activity at 6 g, and dose-related rises in CD8+ T cells and CD19+ B cells. Nine adverse events were reported (7 mild, 1 moderate, 1 severe) and the authors judged up to 9 g a day safe and tolerable. These are blood immune markers, not infections or other clinical outcomes, and no trial shows a benefit above 6 g.
AI-estimated from published studies. Interpret as directional guidance.
L. rhamnosus GG has a higher evidence score (6/10 vs 6/10) and wins in 1 of 3 categories.
For improve digestion, L. rhamnosus GG has a higher relevance score (72 vs 52).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.