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Head-to-head evidence comparison — which supplement is right for you?
Lavender vs SAMe: Lavender has the stronger overall evidence (7.2 vs 6.5/10); they're alternatives for support mood — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Lavender wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Too few graded studies
0 of 1 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Lavender and SAMe have evidence — compare verdict strength side-by-side.
80 mg oral Silexan daily OR aromatherapy inhalation 30–60 min sessions
Evening before bed for sleep and anxiety, Acute use before stressful procedures or events
Oral Silexan capsule (80 mg) for systemic/psychiatric use
400-1,200 mg for mood, 600-1,200 mg for joints. The cited trials used 1,200 mg for knee osteoarthritis and 200 mg a day with probiotics. Label products for mood go up to 1,600 mg, above the highest dose in the cited trials.
On empty stomach, Morning and/or midday
Enteric-coated tablets (SAMe tosylate or butanedisulfonate)
1–4 weeks
1–3 weeks
4–8 weeks
Acute to 2 weeks
2-6 weeks
4-8 weeks
4-8 weeks
Effects of lavender on anxiety: A systematic review and meta-analysis.
Phytomedicine : international journal of phytotherapy and phytopharmacology (2019) · Meta analysis · n=3964
65 RCTs and 25 non-randomised studies were reviewed, and 37 RCTs (3,964 participants) were pooled.
Efficacy of Silexan in patients with anxiety disorders: a meta-analysis of randomized, placebo-controlled trials.
European archives of psychiatry and clinical neuroscience (2023) · Meta analysis · n=1213
Five double-blind placebo-controlled trials of Silexan 80 mg/day for ten weeks in adult outpatients with subthreshold anxiety, mixed anxiety and depressive disorder or generalised anxiety disorder were pooled (n = 1,213).
Efficacy of Silexan in subthreshold anxiety: meta-analysis of randomised, placebo-controlled trials.
European archives of psychiatry and clinical neuroscience (2019) · Meta analysis · n=697
Pooled individual patient data from three placebo-controlled trials in subthreshold anxiety (697 patients), Silexan 80 mg/day for 10 weeks.
S-Adenosylmethionine for osteoarthritis of the knee or hip
The Cochrane database of systematic reviews (2009) · Meta analysis · n=656
Four placebo-controlled trials with 656 patients were included, of poor methodological quality.
Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Neuropsychopharmacology reports (2025) · Meta analysis · n=1049
Eight RCTs comprising 1049 participants met inclusion criteria.
S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Nutrients (2024) · Systematic review
Systematic review of 15 studies of SAMe in liver disease, all rated 4 or 5 out of 5 for quality.
Lavender has a higher evidence score (7.2/10 vs 6.5/10) and wins in 3 of 3 categories.
For support mood, SAMe has a higher relevance score (90 vs 72).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.