Head-to-head evidence comparison — which supplement is right for you?
MCT Oil and Phosphatidylserine are closely matched across evidence, studies, and safety.
1-3 tablespoons (15-45ml) daily
Morning for sustained energy, Before workouts for performance, With coffee (bulletproof style)
C8 (Caprylic Acid) MCT Oil
100-300mg daily
With meals, Evening or post-workout for cortisol
Soy or sunflower-derived phosphatidylserine
30-60 minutes
30-60 minutes
Acute
Acute with excess
4-12 weeks
2 weeks
4-8 weeks
Lipid emulsions for parenterally fed preterm infants
The Cochrane database of systematic reviews (2019) · Meta analysis · n=2037
Meta-analysis examining MCT Oil efficacy
Clinical Benefits of Exogenous Ketosis in Adults with Disease: A Systematic Review
Nutrients (2025) · Systematic review
Exogenous ketosis shows potential in neurological, metabolic, and cardiovascular disorders, while evidence in psychiatric and inflammatory conditions remains scarce and preliminary.
AMPA Receptor Modulation Through Medium-Chain Triglycerides and Decanoic Acid Supports Nutritional Intervention in Pediatric Epilepsy
Nutrients (2025) · Systematic review
Methods: A systematic review was conducted, including articles from January 2000 to January 2025, to explore the potential role of medium-chain triglyceride (MCT) add-on to classic KD and as MCT supplementation in free diets in the management of pediatric drug-resistant epilepsy (DRE).
Safety and efficacy of antioxidant therapy in children and adolescents with attention deficit hyperactivity disorder: A systematic review and network meta-analysis
PloS one (2024) · Meta analysis · n=3650
The rankings of safety and efficacy of the 12 antioxidants vary.
Prevalence of aPhosphatidylserine/prothrombin antibodies and association with antiphospholipid antibody profiles in patients with antiphospholipid syndrome: A systematic review and meta-analysis
Thrombosis research (2022) · Meta analysis · n=1853
Pooled prevalence of aPS/PT IgG alone, IgM alone, and IgG/M were 50.0%, 45.0%, and 65.0%, respectively.
Tie2 protects the vasculature against thrombus formation in systemic inflammation
The Journal of clinical investigation (2018) · Rct · n=1077
Conversely, Tie2 activation normalized prothrombotic responses by inhibiting endothelial tissue factor and phosphatidylserine exposure.
Both MCT Oil and Phosphatidylserine are closely matched — the best choice depends on your specific health goals.
For sharpen focus, MCT Oil has a higher relevance score (70 vs 60).
No known interactions between MCT Oil and Phosphatidylserine have been documented in our database. However, always consult a healthcare provider before combining supplements.