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Head-to-head evidence comparison — which supplement is right for you?
Multivitamin wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
8 of 12 studies with measurable effects showed benefit.
Top outcomes
Verdict
Probably helps
10 of 15 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Multivitamin and Potassium have evidence — compare verdict strength side-by-side.
1 serving daily (as directed on label, typically 1-2 tablets/capsules)
With breakfast, With lunch (if GI sensitive)
Capsule or softgel
99-500mg daily from supplements (food provides more)
With food to reduce GI upset, Spread throughout day, During/after exercise for athletes
Potassium Citrate or Potassium Gluconate
3-6 months
4-8 weeks
2-6 weeks
6-12 weeks
2-4 weeks
1-2 weeks
Long-term
With excess or kidney issues
Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS
The American Journal of Clinical Nutrition (2024) · Meta analysis · n=5765
Multivitamin-mineral supplementation significantly improved global cognition vs placebo (pooled meta-analysis)
Multivitamin Supplementation Improves Memory in Older Adults: A Randomized Clinical Trial
The American Journal of Clinical Nutrition (2023) · Rct · n=3562
Daily multivitamin supplementation for 3 years significantly improved immediate and delayed recall memory
Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial
Alzheimer's & Dementia (2023) · Rct · n=2262
Multivitamin-mineral supplementation (not cocoa extract) drove significant cognitive improvements in COSMOS-Mind
Effect of changes in potassium intake on blood pressure: a dose–response meta-analysis of randomized clinical trials (2000–2024)
Clinical Kidney Journal (2025) · Meta analysis · n=2500
Dose-response analysis of RCTs from 2000-2024
Magnesium and Potassium Supplementation for Systolic Blood Pressure Reduction in the General Normotensive Population: A Systematic Review and Subgroup Meta-Analysis for Optimal Dosage and Treatment Length
Nutrients (2024) · Meta analysis
Both supplements demonstrated greater reductions in SBP for the general population at lower dosages and longer treatment durations.
Sex-specific associations between sodium and potassium intake and overall and cause-specific mortality: a large prospective U.S. cohort study, systematic review, and updated meta-analysis of cohort studies
BMC medicine (2024) · Meta analysis · n=237036
Meta-analysis examining Potassium efficacy
Based on COSMOS trials (n=5765) showing equivalent of 2.0 years cognitive decline prevention. Effects most pronounced in those with cardiovascular disease. Study duration was 3 years. Effectiveness reflects conservative interpretation of memory and global cognition improvements.
AI-estimated from published studies. Interpret as directional guidance.
Multivitamin has a higher evidence score (6/10 vs 8.5/10) and wins in 2 of 3 categories.
For reduce inflammation, Potassium has a higher relevance score (85 vs 50).
No known interactions between Multivitamin and Potassium have been documented in our database. However, always consult a healthcare provider before combining supplements.