Niacinamide vs Thiamidol

Throughout

4-12 weeks

2-12 weeks

2-8 weeks

immediate

12 weeks

2-3 weeks

3 weeks

Niacinamide: A B vitamin that improves aging facial skin appearance.

Dermatol Surg (2005) · Rct · n=50

Double-blind, left-right randomized split-face design: 5% niacinamide vs vehicle applied twice daily for 12 weeks in 50 white women with facial photoaging

The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.

Br J Dermatol (2002) · Rct · n=18

Paired clinical trial: 18 subjects with hyperpigmentation used 5% niacinamide vs vehicle moisturizer (plus a separate facial-tanning arm)

A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma.

Dermatol Res Pract (2011) · Rct · n=27

Split-face RCT in 27 melasma patients: 4% niacinamide vs 4% hydroquinone (HQ) for 8 weeks, both with sunscreen

Inhibition of Human Tyrosinase Requires Molecular Motifs Distinctively Different from Mushroom Tyrosinase

J Invest Dermatol (2018) · In vitro

The discovery paper, and the reason this ingredient exists: most tyrosinase inhibitors were screened against MUSHROOM tyrosinase, which is why so many lack clinical effect.

Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial

J Eur Acad Dermatol Venereol (2021) · Rct · n=50

The comparison that matters: head to head against 4% hydroquinone, the prescription-strength benchmark.

Thiamidol in moderate-to-severe melasma: 24-week, randomized, double-blind, vehicle-controlled clinical study with subsequent regression phase

J Dermatol (2021) · Rct · n=48

The study the abstract calls the FIRST 24-week randomized, double-blind, vehicle-controlled assessment of thiamidol in moderate-to-severe melasma, with a subsequent regression phase.