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Head-to-head evidence comparison — which supplement is right for you?
NMN vs Urolithin A: Urolithin A has the stronger overall evidence (6 vs 5.5/10); they're alternatives for metabolic health — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Urolithin A wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
1 of 1 studies with measurable effects showed benefit.
Top outcomes
Verdict
Too few graded studies
1 of 1 studies with measurable effects showed benefit.
Top outcomes
250-500mg
Morning, With or without food
NMN powder or capsules
500-1000mg
Morning with food
Mitopure (highly pure, bioavailable form)
2-4 weeks
2-4 weeks
Long-term
4-8 weeks
8-16 weeks
8-16 weeks
Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study
Nutrients (2022) · Rct · n=108
Significant interactions were observed between 5-STS and drowsiness. 5-STS of all groups on post-intervention and drowsiness of the NMN_PM and Placebo_PM groups on mid- and post-intervention showed significant improvement compared with those in pre-intervention.
Anti-inflammatory effects of nicotinamide mononucleotide (NMN) in human skeletal muscle after BFR-exercise
Journal of the International Society of Sports Nutrition (2026) · Rct · n=11
Randomised placebo-controlled crossover trial in 11 untrained young men taking NMN 1,200 mg a day for 7 days before blood flow restriction resistance exercise, with muscle biopsies.
The differential impact of three different NAD(+) boosters on circulatory NAD and microbial metabolism in humans
Nature metabolism (2026) · Rct · n=65
Ultimately, we propose a gut-dependent model for the modes of action of the three NAD+ precursors with NR and NMN elevating circulatory NAD+ via the Preiss-Handler pathway, while rapidly absorbed Nam acutely affects NAD+ levels via the salvage pathway.
The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)
The American journal of clinical nutrition (2022) · Rct · n=284
Among 284 participants (88% men; mean age: 51 y; BMI: 31.2 kg/m2; APOE-ε4 genotype = 15.7%), 224 (79%) completed the trial with eligible whole-brain MRIs.
Urolithin A induces mitophagy and prolongs lifespan
Nature Medicine (2016) · Preclinical
Extended lifespan in animal models
Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial
Nature aging (2025) · Rct · n=50
Exploratory single-cell RNA sequencing demonstrated UA-driven transcriptional shifts across immune populations, modulating pathways linked to inflammation and metabolism.
The 300, 600 and 900 mg points come from a 60-day dose-ranging trial in 80 healthy middle-aged adults (PMID 36482258): every dose raised blood NAD against placebo, with the highest levels at 600 and 900 mg, and no safety issues up to 900 mg. The 250 mg point is a 12-week placebo-controlled trial in 60 older adults where blood NAD+ rose (PMID 38789831). A pharmaceutical formulation, MIB-626, gave dose-related NAD increases at 1,000 and 2,000 mg a day for 14 days (PMID 35182418) and is not plotted because it is a different formulation. A higher blood NAD level has not been shown to translate into clinical benefit.
Both doses come from the first-in-human trial in healthy sedentary older adults (PMID 32694802), where 4 weeks of 500 mg or 1,000 mg modulated plasma acylcarnitines and muscle mitochondrial gene expression, with a favourable safety profile at every dose tested. The abstract does not rank the two doses, so the curve is flat. A 4-month trial of 1,000 mg in 66 adults aged 65 to 90 (PMID 35050355) also lowered acylcarnitines and C-reactive protein, but found no gain in maximal ATP production, a direct measure of mitochondrial function. These are biomarkers, not clinical outcomes, and no dose above 1,000 mg was tested.
AI-estimated from published studies. Interpret as directional guidance.
Urolithin A has a higher evidence score (6/10 vs 5.5/10) and wins in 3 of 3 categories.
For metabolic health, NMN has a higher relevance score (80 vs 70).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.