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Head-to-head evidence comparison — which supplement is right for you?
Pelargonium Sidoides vs Zinc: Zinc has the stronger overall evidence (8.5 vs 6.5/10); they're alternatives for support immune system — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Zinc wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Likely helps
13 of 15 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Pelargonium Sidoides and Zinc have evidence — compare verdict strength side-by-side.
Liquid EPs 7630: 30 drops three times daily for adults during an acute infection (the cited trials used this dose in 12 to 18 year olds, and gave adults 30, 60 or 90 mg of EPs 7630 a day as tablets)
Spread through the day
Liquid extract (EPs 7630)
15-25mg daily (a typical label dose, not the dose used in the cited trials, which used about 30 mg a day)
With meals
Zinc picolinate or zinc citrate
and 4 more not shown
Days 4-7 of an acute episode
Within the acute illness window
During use
2-4 weeks
2-4 weeks
4-8 weeks
Immediate
Pelargonium sidoides extract for treating acute respiratory tract infections.
Cochrane Database Syst Rev (2013) · Systematic review · n=10 trials; ~746 adults and ~819 children
Liquid EPs 7630 showed effectiveness for acute bronchitis in both adults and children; tablets did not
Treatment of acute bronchitis with EPs 7630: randomized, controlled trial in children and adolescents.
Pediatr Int (2012) · Rct · n=220 children/adolescents
Significantly greater BSS reduction with EPs 7630 versus placebo (P<0.0001)
Efficacy and tolerability of EPs 7630 tablets in patients with acute bronchitis: a randomised, double-blind, placebo-controlled dose-finding study with a herbal drug preparation from Pelargonium sidoides.
Wien Med Wochenschr (2010) · Rct · n=406 adults
All three active dose groups improved patient-reported outcomes versus placebo at day 7
Efficacy of Zinc Supplementation in the Management of Primary Dysmenorrhea: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis · n=739
Zinc supplementation significantly reduced pain severity compared to placebo (Hedges's g = -1.541; 95% CI: -2.268 to -0.814; p < 0.001), representing a clinically meaningful reduction in pain.
Effects of Daily Zinc Alone or in Combination with Other Nutrient Supplements on the Risk of Malaria Parasitaemia: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Nutrients (2023) · Meta analysis · n=1339
The effect sizes, represented as risk ratios (RRs) with 95% confidence intervals (CIs), were standardised by transforming them into log RRs and then pooling them using a fixed-effects or random-effects model depending on the heterogeneity across studies.
Prevalence of Zinc Deficiency in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Nutrients (2022) · Meta analysis · n=806
Pooled analyses by the IBD subgroup showed a total population of 1677 with CD, for an overall mean zinc deficiency prevalence of 54% and 95% confidence intervals (CI) ranging from 0.51 to 0.56, versus 41% (95%CI 0.38-0.45) in the UC population (n = 806).
Zinc has a higher evidence score (8.5/10 vs 6.5/10) and wins in 3 of 3 categories.
For support immune system, Zinc has a higher relevance score (90 vs 62).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
AREDS2 works for diagnosed AMD; lutein/screen-strain claims are weaker. Who actually benefits.
The popular one (saw palmetto) mostly fails in rigorous trials; beta-sitosterol is the better bet.
Selenium helps; iodine can WORSEN Hashimoto’s. The honest take on "thyroid support".
CoQ10, zinc, selenium, carnitine modestly help sperm parameters — but live-birth evidence is weak.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.