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Head-to-head evidence comparison — which supplement is right for you?
Pelargonium Sidoides vs Vitamin B12: Vitamin B12 has the stronger overall evidence (7.5 vs 6.5/10); the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Vitamin B12 wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Likely helps
5 of 6 studies with measurable effects showed benefit.
Top outcomes
Liquid EPs 7630: 30 drops three times daily for adults during an acute infection (the cited trials used this dose in 12 to 18 year olds, and gave adults 30, 60 or 90 mg of EPs 7630 a day as tablets)
Spread through the day
Liquid extract (EPs 7630)
500-1000mcg daily for maintenance; higher for deficiency
Morning (may be energizing), With or without food
Methylcobalamin (sublingual)
Days 4-7 of an acute episode
Within the acute illness window
During use
2-4 weeks
4-8 weeks
Weeks to months
Pelargonium sidoides extract for treating acute respiratory tract infections.
Cochrane Database Syst Rev (2013) · Systematic review · n=10 trials; ~746 adults and ~819 children
Liquid EPs 7630 showed effectiveness for acute bronchitis in both adults and children; tablets did not
Treatment of acute bronchitis with EPs 7630: randomized, controlled trial in children and adolescents.
Pediatr Int (2012) · Rct · n=220 children/adolescents
Significantly greater BSS reduction with EPs 7630 versus placebo (P<0.0001)
Efficacy and tolerability of EPs 7630 tablets in patients with acute bronchitis: a randomised, double-blind, placebo-controlled dose-finding study with a herbal drug preparation from Pelargonium sidoides.
Wien Med Wochenschr (2010) · Rct · n=406 adults
All three active dose groups improved patient-reported outcomes versus placebo at day 7
Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Irish journal of medical science (2024) · Meta analysis · n=4275
Regarding the hemoglobin level, the pooled effect sizes showed no difference between all routes of administration that could reach statistical significance.
Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review
The American journal of clinical nutrition (2024) · Meta analysis · n=76664
In areas without and with partial folic acid fortification, combined B-vitamin supplementation significantly reduced the risk of stroke by 34% [RR: 0.66; 95% confidence interval (CI): 0.50, 0.86] and 11% (RR: 0.89; 95% CI: 0.79, 1.00), respectively.
Vitamin Status in Patients with Phenylketonuria: A Systematic Review and Meta-Analysis
International journal of molecular sciences (2024) · Meta analysis · n=3157
24 studies compared 770 people with early-treated PKU and 2387 healthy controls.
Vitamin B12 has a higher evidence score (7.5/10 vs 6.5/10) and wins in 3 of 3 categories.
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
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The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.