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Head-to-head evidence comparison — which supplement is right for you?
Pomegranate vs Saccharomyces Boulardii: they're closely matched on evidence (5.6 vs 8.5/10); they're alternatives for inflammation-related symptoms — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Pomegranate and Saccharomyces Boulardii are closely matched across evidence, studies, and safety.
Verdict
Too few graded studies
Top outcomes
Verdict
Likely helps
4 of 4 studies with measurable effects showed benefit.
Top outcomes
~500-1000mg pomegranate extract (standardized to ellagic acid/punicalagins) or ~250-500ml juice daily. These are typical label doses. The cited studies are reviews and do not state a trial dose.
With meals
Standardized extract
250-500mg (5-10 billion CFU) daily
With or without food, At least 2 hours away from antifungals
Capsules (lyophilized)
4-12 weeks
4-12 weeks
Throughout use
During use
1-3 days
1-2 weeks
Does pomegranate consumption improve oxidative stress? A systematic review and meta-analysis of randomized controlled clinical trials.
Clinical nutrition ESPEN (2022) · Meta analysis
Systematic review and meta-analysis of 21 randomised controlled trials of pomegranate and oxidative-stress markers
Lipid profile changes after pomegranate consumption: A systematic review and meta-analysis of randomized controlled trials.
Phytomedicine : international journal of phytotherapy and phytopharmacology (2016) · Meta analysis · n=545
Meta-analysis of 12 randomised placebo-controlled trials (13 treatment arms, 545 participants)
Effect of food sources of nitrate, polyphenols, L-arginine and L-citrulline on endurance exercise performance: a systematic review and meta-analysis of randomised controlled trials.
Journal of the International Society of Sports Nutrition (2021) · Meta analysis
Meta-analysis of 118 studies of foods rich in nitrate, polyphenols, L-arginine or L-citrulline, measuring endurance exercise performance, not vascular function
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis
Frontiers in cellular and infection microbiology (2025) · Meta analysis · n=5036
Meta-analysis of 19 studies with 5,036 people with H. pylori infection, adding S. boulardii to standard eradication therapy.
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Gut microbes (2024) · Meta analysis · n=2871
This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut.
Both points come from a meta-analysis of 10 randomised trials adding S. boulardii to bismuth quadruple therapy (PMID 40251486), whose dose subgroups found the same gain in eradication at 500 mg a day (RR 1.10, 95% CI 1.03 to 1.17) and 1000 mg a day (RR 1.08, 95% CI 1.03 to 1.12). Effectiveness is the relative gain in eradication in percent. Total adverse effects fell with S. boulardii (RR 0.53), so the side effect values are low. The authors recommend 500 mg a day for more than 10 days. The effect is as an add-on to antibiotics only, and doses are in mg of product, not CFU.
AI-estimated from published studies. Interpret as directional guidance.
Both Pomegranate and Saccharomyces Boulardii are closely matched — the best choice depends on your specific health goals.
For inflammation-related symptoms, Saccharomyces Boulardii has a higher relevance score (40 vs 35).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.