Loading…
We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Head-to-head evidence comparison — which supplement is right for you?
Pomegranate vs Saccharomyces Boulardii: they're closely matched on evidence (5.6 vs 8.5/10); they're alternatives for inflammation-related symptoms — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Pomegranate and Saccharomyces Boulardii are closely matched across evidence, studies, and safety.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Likely helps
13 of 15 studies with measurable effects showed benefit.
Top outcomes
~500-1000mg pomegranate extract (standardized to ellagic acid/punicalagins) or ~250-500ml juice daily
with-meals
Standardized extract
250-500mg (5-10 billion CFU) daily
With or without food, At least 2 hours away from antifungals
Capsules (lyophilized)
4-12 weeks
4-12 weeks
Throughout use
During use
1-3 days
1-2 weeks
Does pomegranate consumption improve oxidative stress? A systematic review and meta-analysis of randomized controlled clinical trials.
Clinical nutrition ESPEN (2022) · Meta analysis
Improved antioxidant/oxidative-stress markers
Lipid profile changes after pomegranate consumption: A systematic review and meta-analysis of randomized controlled trials.
Phytomedicine : international journal of phytotherapy and phytopharmacology (2016) · Meta analysis
No significant effect on cholesterol/triglycerides
Effect of food sources of nitrate, polyphenols, L-arginine and L-citrulline on endurance exercise performance: a systematic review and meta-analysis of randomised controlled trials.
Journal of the International Society of Sports Nutrition (2021) · Meta analysis
Pomegranate among polyphenol sources affecting vascular function
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis
Frontiers in cellular and infection microbiology (2025) · Meta analysis · n=5036
S. boulardii supplementation in traditional eradication therapy significantly improves the H. pylori eradication rate and reduces the total adverse effects and incidence of diarrhea, bloating, constipation, and nausea.
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Gut microbes (2024) · Meta analysis · n=2871
This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut.
Based on multiple meta-analyses showing 1.1-1.6 day reduction in diarrhea duration. Effect size appears to plateau at standard therapeutic doses. Limited data on doses above 20 billion CFU.
AI-estimated from published studies. Interpret as directional guidance.
Both Pomegranate and Saccharomyces Boulardii are closely matched — the best choice depends on your specific health goals.
For inflammation-related symptoms, Saccharomyces Boulardii has a higher relevance score (90 vs 55).
No known interactions between Pomegranate and Saccharomyces Boulardii have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.