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Head-to-head evidence comparison — which supplement is right for you?
Probiotics wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
30 of 39 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
5 of 5 studies with measurable effects showed benefit.
Top outcomes
10-20 billion CFU
With or without food (strain-dependent), Same time daily for consistency
Capsules with multiple strains
250-500mg daily for general support; up to 1500mg for therapeutic use
With meals containing fat, Before or with fatty meals
TUDCA capsules (pure tauroursodeoxycholic acid)
2-4 weeks
4-8 weeks
4-8 weeks
First 1-2 weeks
4-8 weeks
1-2 weeks
8-12 weeks
Preventive Effect of Probiotics on Oral Mucositis Induced by Cancer Treatment: A Systematic Review and Meta-Analysis
International journal of molecular sciences (2022) · Meta analysis · n=708
Three trials using Lactobacilli-based probiotics reported that the incidence of oral mucositis in the probiotic group was significantly low (risk ratio [RR] = 0.84, 95% confidence interval [CI] = 0.77−0.93, p = 0.0004).
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
The Cochrane database of systematic reviews (2017) · Meta analysis · n=9955
A complete case analysis (i.e. participants who completed the study) among trials investigating CDAD (31 trials, 8672 participants) suggests that probiotics reduce the risk of CDAD by 60%.
The bile acid TUDCA and neurodegenerative disorders: An overview
Life sciences (2021) · Systematic review
The tauroursodeoxycholic acid (TUDCA), one of the acids found in bear bile, is a hydrophilic bile acid and naturally produced in the liver by conjugation of taurine to ursodeoxycholic acid (UDCA).
Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure
International journal of molecular sciences (2021) · Systematic review
The potential advantages of whole-food plant-based diets, moderation in salt intake, avoidance of phosphate additives, and regular exercise training and sauna sessions are also discussed.
Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis
The New England Journal of Medicine (2020) · Rct · n=137
A total of 137 participants were randomly assigned in a 2:1 ratio to receive sodium phenylbutyrate-taurursodiol (89 participants) or placebo (48 participants).
Based on meta-analyses showing benefits for IBS and digestive symptoms. Effect sizes varied considerably between studies with low to very low certainty of evidence. Initial GI symptoms common when starting but typically resolve within 1-2 weeks.
Based on one phase 3 RCT in ALS showing modest functional improvement and systematic reviews suggesting neuroprotective effects. Effect size is conservative given single disease population study and limited human data for other neurological conditions.
AI-estimated from published studies. Interpret as directional guidance.
Probiotics has a higher evidence score (9/10 vs 6/10) and wins in 2 of 3 categories.
Both Probiotics and TUDCA score equally (95) for reduce inflammation.
No known interactions between Probiotics and TUDCA have been documented in our database. However, always consult a healthcare provider before combining supplements.