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Head-to-head evidence comparison — which supplement is right for you?
Pygeum vs Rye Pollen Extract: Pygeum has the stronger overall evidence (5.5 vs 4.8/10); they're alternatives for prostate health — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Pygeum wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
2 of 2 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (2)
Outcomes where both Pygeum and Rye Pollen Extract have evidence — compare verdict strength side-by-side.
100-200mg standardized extract daily
Once or twice daily, With or without food
Standardized extract (13-14% sterols)
2 capsules/tablets three times daily (every 8 hours), or 375-750 mg twice daily
Three divided doses per day, roughly every 8 hours, With or without food — no trial specified a meal requirement
Cernilton / Cernitin standardized rye-grass pollen extract
6-8 weeks
6-8 weeks
8-12 weeks
12-24 weeks
12-24 weeks
6-12 weeks
6-12 weeks
What do we know about phytotherapy of benign prostatic hyperplasia?
Life sciences (2015) · Review
On the basis of preclinical studies several mechanisms of action have been postulated, including 5alpha-reductase inhibition, alpha-adrenergic antagonism, dihydrotestosterone and estrogen receptor inhibition.
Phytotherapy of benign prostatic hyperplasia. A minireview
Phytotherapy research : PTR (2014) · Review
Histological BPH, which typically develops after the age of 40 years, ranges in prevalence from >50% at 60 years to as high as 90% by 85 years of age.
Benign prostatic hyperplasia and male lower urinary tract symptoms (LUTS)
BMJ clinical evidence (2011) · Systematic review
We found 63 systematic reviews, RCTs, or observational studies that met our inclusion criteria.
Cernilton for benign prostatic hyperplasia
Cochrane Database of Systematic Reviews (2000) · Systematic review · n=444
444 men were enrolled in 2 placebo-controlled and 2 comparative trials lasting from 12 to 24 weeks; three used a double-blind method although treatment allocation concealment was unclear in all.
A pollen extract (Cernilton) in patients with inflammatory chronic prostatitis-chronic pelvic pain syndrome: a multicentre, randomised, prospective, double-blind, placebo-controlled phase 3 study
European Urology (2009) · Rct · n=139
139 men with NIH category IIIA CP/CPPS were randomised to pollen extract (n=70) or placebo (n=69), dosed as two capsules every 8 hours for 12 weeks.
A systematic review of Cernilton for the treatment of benign prostatic hyperplasia
BJU International (2000) · Systematic review · n=444
444 men were enrolled in two placebo-controlled and two comparative trials lasting 12-24 weeks; concealment of treatment allocation was unclear in all.
Based on Cochrane review (n=1562) and network meta-analysis showing modest benefits. Evidence quality noted as low-to-moderate due to dated methodology in available RCTs. Most studies used standardized bark extract.
AI-estimated from published studies. Interpret as directional guidance.
Pygeum has a higher evidence score (5.5/10 vs 4.8/10) and wins in 2 of 3 categories.
For prostate health, Pygeum has a higher relevance score (80 vs 78).
No known interactions between Pygeum and Rye Pollen Extract have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.