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Head-to-head evidence comparison — which supplement is right for you?
Rye Pollen Extract vs Stinging Nettle Root: Stinging Nettle Root has the stronger overall evidence (5.5 vs 4.8/10); they're alternatives for prostate health — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Stinging Nettle Root wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Likely helps
3 of 3 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Rye Pollen Extract and Stinging Nettle Root have evidence — compare verdict strength side-by-side.
2 capsules/tablets three times daily (every 8 hours), or 375-750 mg twice daily
Three divided doses per day, roughly every 8 hours, With or without food — no trial specified a meal requirement
Cernilton / Cernitin standardized rye-grass pollen extract
300-450 mg root extract a day (the cited trials used 450 mg of nettle root extract a day for 12 weeks, and 459 mg of dry root extract a day for 1 year). Label products go up to 600 mg, above the highest dose in the cited trials.
With meals, Split into 2-3 doses
Standardized root extract
and 1 more not shown
12-24 weeks
12-24 weeks
6-12 weeks
6-12 weeks
4-8 weeks
4-8 weeks
Therapeutic efficacy of orally administered pollen for nonallergic diseases: An umbrella review.
Phytotherapy Research (2019) · Systematic review
Reviews support grass pollen extracts for symptomatic BPH and chronic prostatitis
A pollen extract (Cernilton) in patients with inflammatory chronic prostatitis-chronic pelvic pain syndrome: a multicentre, randomised, prospective, double-blind, placebo-controlled phase 3 study
European Urology (2009) · Rct · n=139
139 men with NIH category IIIA CP/CPPS were randomised to pollen extract (n=70) or placebo (n=69), dosed as two capsules every 8 hours for 12 weeks.
A systematic review of Cernilton for the treatment of benign prostatic hyperplasia
BJU International (2000) · Systematic review · n=444
444 men were enrolled in two placebo-controlled and two comparative trials lasting 12-24 weeks; concealment of treatment allocation was unclear in all.
The effect of nettle (Urtica dioica) supplementation on the glycemic control of patients with type 2 diabetes mellitus: A systematic review and meta-analysis
Phytotherapy research : PTR (2020) · Meta analysis · n=401
Not the root indication. The evidence base for stinging nettle root (Urtica dioica) is BPH and lower urinary tract symptoms, and this study is about glycemic control in type 2 diabetes. The abstract does not state which part of the plant was used. Read it as species-level context, not as root evidence.
Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms
International journal of molecular sciences (2018) · Review
Not the root indication. The evidence base for stinging nettle root (Urtica dioica) is BPH and lower urinary tract symptoms, and this study is about kidney-stone prevention. The paper describes a leaf/aerial preparation. Read it as species-level context, not as root evidence.
Plant food supplements with anti-inflammatory properties: a systematic review (II)
Critical reviews in food science and nutrition (2013) · Systematic review
Not the root indication. The evidence base for stinging nettle root (Urtica dioica) is BPH and lower urinary tract symptoms, and this study is about anti-inflammatory effects. The abstract does not state which part of the plant was used. Read it as species-level context, not as root evidence.
Stinging Nettle Root has a higher evidence score (5.5/10 vs 4.8/10) and wins in 2 of 3 categories.
For prostate health, Stinging Nettle Root has a higher relevance score (80 vs 78).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.