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Head-to-head evidence comparison — which supplement is right for you?
Rye Pollen Extract vs Stinging Nettle Root: Stinging Nettle Root has the stronger overall evidence (5.5 vs 4.8/10); they're alternatives for prostate health — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Stinging Nettle Root wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Likely helps
7 of 7 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Rye Pollen Extract and Stinging Nettle Root have evidence — compare verdict strength side-by-side.
2 capsules/tablets three times daily (every 8 hours), or 375-750 mg twice daily
Three divided doses per day, roughly every 8 hours, With or without food — no trial specified a meal requirement
Cernilton / Cernitin standardized rye-grass pollen extract
300-600mg root extract
With meals, Split into 2-3 doses
Standardized root extract
and 1 more not shown
12-24 weeks
12-24 weeks
6-12 weeks
6-12 weeks
4-8 weeks
4-8 weeks
Therapeutic efficacy of orally administered pollen for nonallergic diseases: An umbrella review.
Phytotherapy Research (2019) · Systematic review
Reviews support grass pollen extracts for symptomatic BPH and chronic prostatitis
A pollen extract (Cernilton) in patients with inflammatory chronic prostatitis-chronic pelvic pain syndrome: a multicentre, randomised, prospective, double-blind, placebo-controlled phase 3 study
European Urology (2009) · Rct · n=139
139 men with NIH category IIIA CP/CPPS were randomised to pollen extract (n=70) or placebo (n=69), dosed as two capsules every 8 hours for 12 weeks.
A systematic review of Cernilton for the treatment of benign prostatic hyperplasia
BJU International (2000) · Systematic review · n=444
444 men were enrolled in two placebo-controlled and two comparative trials lasting 12-24 weeks; concealment of treatment allocation was unclear in all.
The effect of nettle (Urtica dioica) supplementation on the glycemic control of patients with type 2 diabetes mellitus: A systematic review and meta-analysis
Phytotherapy research : PTR (2020) · Meta analysis · n=401
⚠️ NOT THE ROOT INDICATION. This entry is Urtica dioica ROOT, whose evidence base is BPH and lower urinary tract symptoms; this study is about glycemic control in type 2 diabetes. The abstract does not state which part of the plant was used. Read it as species-level context, not as root evidence.
Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms
International journal of molecular sciences (2018) · Review
⚠️ NOT THE ROOT INDICATION. This entry is Urtica dioica ROOT, whose evidence base is BPH and lower urinary tract symptoms; this study is about kidney-stone prevention. The paper describes a LEAF/aerial preparation. Read it as species-level context, not as root evidence.
Plant food supplements with anti-inflammatory properties: a systematic review (II)
Critical reviews in food science and nutrition (2013) · Systematic review
⚠️ NOT THE ROOT INDICATION. This entry is Urtica dioica ROOT, whose evidence base is BPH and lower urinary tract symptoms; this study is about anti-inflammatory effects. The abstract does not state which part of the plant was used. Read it as species-level context, not as root evidence.
Based on multiple RCTs showing IPSS improvements in BPH patients. Most studies used combination formulations with saw palmetto. Effect magnitude conservative due to mixed study designs and combination treatments.
AI-estimated from published studies. Interpret as directional guidance.
Stinging Nettle Root has a higher evidence score (5.5/10 vs 4.8/10) and wins in 2 of 3 categories.
For prostate health, Stinging Nettle Root has a higher relevance score (80 vs 78).
No known interactions between Rye Pollen Extract and Stinging Nettle Root have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.