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Urtica dioica (Nettle Root)
Herbal support for prostate health and urinary symptoms, often combined with saw palmetto for BPH.
What the evidence says
Stinging Nettle Root appears to help in 7 of 7 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2005–2024 with a typical study size of 72 participants.
Based on 24 studies · 3 meta-analyses · 18 RCTs · 3,239 total participants
Confidence
HighWhat the studies found
By outcome
See full supplement plans that include Stinging Nettle Root.
Stinging Nettle Root has an evidence score of 8.5/10 — very strong evidence based on 24 indexed studies, including 3 meta-analyses. Herbal support for prostate health and urinary symptoms, often combined with saw palmetto for BPH.
The commonly studied dose of Stinging Nettle Root is 300-600mg root extract. Research points to an estimated optimal dose around 480mg, with a minimum effective dose near 240mg. Individual response varies — start low and adjust.
Timing is flexible for Stinging Nettle Root — consistent daily use matters more than the time of day. Stinging nettle root (Urtica dioica) contains lignans, lectins, and polysaccharides that modulate sex hormone-binding globulin (SHBG) and 5-alpha-reductase activity.
Fenugreek
Likely helpsTraditional herb with evidence for supporting testosterone, libido, blood sugar control, and lactation.
Pumpkin Seed Oil
Mostly mechanism / observationalA cold-pressed oil rich in phytosterols, zinc, and unsaturated fatty acids shown to support prostate health, hair growth, cardiovascular function, and hormonal balance.
Last reviewed May 2026 · evidence from 31 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Stinging Nettle Root (different from nettle leaf used for allergies) has been used in Europe for decades to support prostate health. It works through different mechanisms than saw palmetto, making them complementary. Research shows benefits for urinary symptoms associated with BPH. Also used for general prostate support and hormonal balance.
Affects hormone binding in prostate
May affect estrogen production
May slow prostate cell growth
How Stinging Nettle Root works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
300-600mg root extract
Take with food
| Form | Type |
|---|---|
| 💊Standardized root extract | Recommended |
| 💊Dried root capsules | Alternative |
| 💧Tincture | Alternative |
Use ROOT extract specifically — leaf is different and used for allergies. Often combined with saw palmetto.
Minimum: 4 weeks
Optimal: 12 weeks
Cycling: Not required
Note: Can be taken any time with food.
Based on multiple RCTs showing IPSS improvements in BPH patients. Most studies used combination formulations with saw palmetto. Effect magnitude conservative due to mixed study designs and combination treatments.
Better urinary flow
Fewer nighttime bathroom trips
Not typically used; insufficient data
May have mild effects on blood clotting
May have mild diuretic effects
May affect blood sugar
Tip: Take with food
Tip: Normal effect
Stinging Nettle Root is generally well-tolerated and considered safe for most healthy adults at recommended doses. The most commonly reported side effects are GI upset, mild diuresis. Use caution if any of these apply to you: Known allergy or hypersensitivity to Stinging Nettle Root or related compounds; Pregnancy and breastfeeding; Kidney disease.
Soy Isoflavones
Likely helpsPlant compounds with weak estrogenic effects that support menopausal symptoms, bone health, and cardiovascular function.
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