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Head-to-head evidence comparison — which supplement is right for you?
Saccharomyces Boulardii and TUDCA are closely matched across evidence, studies, and safety.
Verdict
Likely helps
13 of 15 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
5 of 5 studies with measurable effects showed benefit.
Top outcomes
250-500mg (5-10 billion CFU) daily
With or without food, At least 2 hours away from antifungals
Capsules (lyophilized)
250-500mg daily for general support; up to 1500mg for therapeutic use
With meals containing fat, Before or with fatty meals
TUDCA capsules (pure tauroursodeoxycholic acid)
During use
1-3 days
1-2 weeks
4-8 weeks
1-2 weeks
8-12 weeks
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis
Frontiers in cellular and infection microbiology (2025) · Meta analysis · n=5036
S. boulardii supplementation in traditional eradication therapy significantly improves the H. pylori eradication rate and reduces the total adverse effects and incidence of diarrhea, bloating, constipation, and nausea.
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Gut microbes (2024) · Meta analysis · n=2871
This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut.
The bile acid TUDCA and neurodegenerative disorders: An overview
Life sciences (2021) · Systematic review
The tauroursodeoxycholic acid (TUDCA), one of the acids found in bear bile, is a hydrophilic bile acid and naturally produced in the liver by conjugation of taurine to ursodeoxycholic acid (UDCA).
Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure
International journal of molecular sciences (2021) · Systematic review
The potential advantages of whole-food plant-based diets, moderation in salt intake, avoidance of phosphate additives, and regular exercise training and sauna sessions are also discussed.
Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis
The New England Journal of Medicine (2020) · Rct · n=137
A total of 137 participants were randomly assigned in a 2:1 ratio to receive sodium phenylbutyrate-taurursodiol (89 participants) or placebo (48 participants).
Based on multiple meta-analyses showing 1.1-1.6 day reduction in diarrhea duration. Effect size appears to plateau at standard therapeutic doses. Limited data on doses above 20 billion CFU.
Based on one phase 3 RCT in ALS showing modest functional improvement and systematic reviews suggesting neuroprotective effects. Effect size is conservative given single disease population study and limited human data for other neurological conditions.
AI-estimated from published studies. Interpret as directional guidance.
Both Saccharomyces Boulardii and TUDCA are closely matched — the best choice depends on your specific health goals.
For reduce inflammation, TUDCA has a higher relevance score (95 vs 90).
No known interactions between Saccharomyces Boulardii and TUDCA have been documented in our database. However, always consult a healthcare provider before combining supplements.