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Head-to-head evidence comparison — which supplement is right for you?
Saccharomyces Boulardii and Turkey Tail are closely matched across evidence, studies, and safety.
Verdict
Likely helps
13 of 15 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mixed evidence
1 of 3 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (2)
Outcomes where both Saccharomyces Boulardii and Turkey Tail have evidence — compare verdict strength side-by-side.
250-500mg (5-10 billion CFU) daily
With or without food, At least 2 hours away from antifungals
Capsules (lyophilized)
1-3g dried mushroom or equivalent extract
With or without food
Hot water extract capsules or powder
During use
1-3 days
1-2 weeks
4-8 weeks
4-8 weeks
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis
Frontiers in cellular and infection microbiology (2025) · Meta analysis · n=5036
S. boulardii supplementation in traditional eradication therapy significantly improves the H. pylori eradication rate and reduces the total adverse effects and incidence of diarrhea, bloating, constipation, and nausea.
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Gut microbes (2024) · Meta analysis · n=2871
This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut.
Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer
International journal of molecular sciences (2023) · Systematic review
In this article, we reviewed mushrooms showing antineoplastic activity again breast cancer cells, especially focusing on the possible bioactive compounds involved and their mechanisms of action.
Coriolus (Trametes) versicolor mushroom to reduce adverse effects from chemotherapy or radiotherapy in people with colorectal cancer
The Cochrane database of systematic reviews (2022) · Systematic review · n=1569
We found low-certainty evidence of a small effect of adjunctive Coriolus on improved survival at five years compared with no adjunctive care (RR 1.08, 95% CI 1.01 to 1.15; 1094 participants; 3 studies; number needed to benefit (NNTB) = 16 (95% Cl 9 to 70).
Current Advancements in Antitumor Properties and Mechanisms of Medicinal Components in Edible Mushrooms
Nutrients (2022) · Systematic review
Our review summarizes the research progress on the anticancer properties of edible and medicinal fungi and the underlying molecular mechanism, which may offer a better understanding of this field.
Based on multiple meta-analyses showing 1.1-1.6 day reduction in diarrhea duration. Effect size appears to plateau at standard therapeutic doses. Limited data on doses above 20 billion CFU.
Based on systematic reviews and clinical studies using PSK/PSP extracts. Most studies used standardized polysaccharide extracts, not raw mushroom powder. Effects may be significantly lower with mycelium-on-grain products due to poor bioavailability.
AI-estimated from published studies. Interpret as directional guidance.
Both Saccharomyces Boulardii and Turkey Tail are closely matched — the best choice depends on your specific health goals.
For reduce inflammation, Saccharomyces Boulardii has a higher relevance score (90 vs 65).
No known interactions between Saccharomyces Boulardii and Turkey Tail have been documented in our database. However, always consult a healthcare provider before combining supplements.