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Head-to-head evidence comparison — which supplement is right for you?
Saccharomyces Boulardii and Vitamin C are closely matched across evidence, studies, and safety.
Verdict
Likely helps
13 of 15 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
12 of 17 studies with measurable effects showed benefit.
Top outcomes
250-500mg (5-10 billion CFU) daily
With or without food, At least 2 hours away from antifungals
Capsules (lyophilized)
500-1000mg
With meals, Split doses if taking >500mg
Ascorbic acid or buffered vitamin C
During use
1-3 days
1-2 weeks
Ongoing
1-2 weeks
4-8 weeks
With high doses (>2g)
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis
Frontiers in cellular and infection microbiology (2025) · Meta analysis · n=5036
S. boulardii supplementation in traditional eradication therapy significantly improves the H. pylori eradication rate and reduces the total adverse effects and incidence of diarrhea, bloating, constipation, and nausea.
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Gut microbes (2024) · Meta analysis · n=2871
This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut.
Vitamin C supplementation for prevention and treatment of pneumonia
The Cochrane database of systematic reviews (2020) · Meta analysis · n=2774
We are uncertain of the effect of vitamin C supplementation on mortality due to pneumonia (RR 0.21, 95% CI 0.03 to 1.66; 1 study, 57 participants; very low-quality evidence).
Vitamin C supplementation in pregnancy
The Cochrane database of systematic reviews (2015) · Meta analysis · n=20038
Conversely, the risk of term PROM was increased when supplementation included vitamin C and vitamin E (average RR 1.73, 95% CI 1.34 to 2.23; 3060 participants; two studies; I² = 0%).
Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults
Nutrients (2025) · Systematic review
Most studies (77%) had a low risk of bias.
Based on multiple meta-analyses showing 1.1-1.6 day reduction in diarrhea duration. Effect size appears to plateau at standard therapeutic doses. Limited data on doses above 20 billion CFU.
Based on 3 meta-analyses of sepsis patients. One study showed RR 0.60 for mortality reduction, but another showed increased risk (RR 1.21). Evidence quality rated as low to very low. Effect limited to intravenous administration in critically ill patients.
AI-estimated from published studies. Interpret as directional guidance.
Both Saccharomyces Boulardii and Vitamin C are closely matched — the best choice depends on your specific health goals.
For reduce inflammation, Saccharomyces Boulardii has a higher relevance score (90 vs 65).
No known interactions between Saccharomyces Boulardii and Vitamin C have been documented in our database. However, always consult a healthcare provider before combining supplements.