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Head-to-head evidence comparison — which supplement is right for you?
Spearmint vs Testosterone (TRT): Spearmint has the stronger overall evidence (6.2 vs 5.6/10); the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Spearmint wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Too few graded studies
Top outcomes
900 mg/day of standardized spearmint extract (or 2 cups of spearmint herbal tea daily)
Morning with breakfast, Evening with dinner (split dosing mirrors clinical trial protocols)
Standardized aqueous extract (high-rosmarinic acid)
Prescription-only and clinician-directed — this is a controlled substance, NOT a self-administered supplement, and we do not provide a non-medical dosing protocol. For context only: TRT for diagnosed hypogonadism is titrated to a mid-normal testosterone level. Intramuscular testosterone esters (cypionate/enanthate) are commonly dosed around 50–100 mg weekly (or ~100–200 mg every 2 weeks); long-acting testosterone undecanoate is dosed less frequently. Transdermal gels (~50–100 mg/day applied) and subcutaneous injection are alternative routes. Supraphysiologic anabolic-steroid doses are far higher and dangerous — not a regimen this library endorses.
Any time of day
Clinician-prescribed testosterone (intramuscular ester or transdermal gel) for diagnosed hypogonadism — controlled substance, prescription-only
and 1 more not shown
2–4 weeks
4–12 weeks
4–8 weeks
8–16 weeks
Weeks to months
Months
Months
Throughout use
An evidence-based systematic review of spearmint by the natural standard research collaboration.
Journal of dietary supplements (2010) · Systematic review
An evidence-based systematic review of spearmint (Mentha spicata, Mentha viridis) including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
A systematic review of the efficacy of alternative medicine in the treatment of nausea and vomiting of pregnancy.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology (2020) · Systematic review
Spearmint syrup is listed among several herbal options the authors call effective for mild to moderate nausea and vomiting of pregnancy.
Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. A randomized controlled trial.
Phytotherapy research : PTR (2010) · Rct · n=42
Forty-one of 42 women with PCOS completed this 30-day RCT comparing spearmint tea twice daily with a placebo herbal tea.
Effects of Testosterone Treatment in Older Men.
The New England journal of medicine (2016) · Rct · n=790
The coordinated Testosterone Trials: 790 men aged 65 or older with testosterone below 275 ng/dl and symptoms, testosterone gel or placebo gel for one year, each man in one or more of the Sexual Function, Physical Function and Vitality Trials.
Cardiovascular Safety of Testosterone-Replacement Therapy.
The New England journal of medicine (2023) · Rct · n=5246
TRAVERSE: a randomized, double-blind, placebo-controlled noninferiority trial of daily 1.62% testosterone gel in 5,246 men aged 45 to 80 with hypogonadism and existing or high risk of cardiovascular disease, mean follow-up 33 months.
Safety and Efficacy of Testosterone Therapy on Musculoskeletal Health and Clinical Outcomes in Men: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.
Endocrine practice (2023) · Meta analysis · n=1728
Systematic review and meta-analysis of 16 randomized placebo-controlled trials (1,728 men, mean age 77) of testosterone therapy on bone, muscle, fat and strength.
Both points come from one 90-day RCT in 90 adults with age-associated memory impairment, 30 per arm, at 0, 600 or 900 mg of extract a day (PMID 29314866). Quality of working memory improved by 15% and spatial working memory accuracy by 9% versus placebo at 900 mg only, so 600 mg is plotted as no effect. The same trial found no effect of either dose on safety markers over 90 days (PMID 28286189). No dose above 900 mg was tested, and the effect may be smaller in people without memory complaints.
AI-estimated from published studies. Interpret as directional guidance.
Spearmint has a higher evidence score (6.2/10 vs 5.6/10) and wins in 2 of 3 categories.
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.