Compare Supplements

Side-by-side comparison of 2 supplements

🧬

Methylfolate

9/10high

🔵

Myo-Inositol

9/10high

Evidence

Evidence Score9/10

Studies: 40+

Meta-analyses: 6

Evidence Score9/10

Studies: 39+

Meta-analyses: 20

Dosage & Timing

Dosage:

400-800mcg daily

Best Time:

Morning with or without food, Consistent daily timing

Can take on empty stomach

Form:

L-Methylfolate (5-MTHF)

Dosage:

2-4g daily for PCOS; up to 12-18g for anxiety

Best Time:

Divided doses with meals, Morning and evening

Take with food

Form:

Myo-inositol powder

What You'll Notice

😊 Improved Mood70%

2-4 weeks

⚡ Increased Energy65%

1-3 weeks

❤️ Lower Homocysteine80%

4-8 weeks

🌸 Improved Ovulation75%

3-6 months

😌 Reduced Anxiety70%

4-6 weeks

📊 Better Insulin Sensitivity70%

2-3 months

Safety

high safety rating

Contraindications:

History of bipolar disorder (may trigger mania - start very low)
Seizure disorders (high doses)

Drug Interactions:

Methotrexate
Anti-seizure medications

Side Effects:

Anxiety/irritabilityInsomniaHeadache

high safety rating

Contraindications:

Bipolar disorder (may trigger mania at high doses)

Drug Interactions:

Lithium
Diabetes medications

Side Effects:

NauseaDiarrhea

Works Well With

B-Complex (Methylated)complementary

L-Methionineenhances

Myo-Inositolcomplementary

Methylfolatecomplementary

Spearmintcomplementary

How They Work Together

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Compare Supplements

Methylfolate

Myo-Inositol

Evidence

Dosage & Timing

What You'll Notice

Safety

Works Well With

Categories

How They Work Together

Compare Supplements

Methylfolate

Myo-Inositol

Evidence

Dosage & Timing

What You'll Notice

Safety

Works Well With

Categories

How They Work Together