Compare Supplements

Prescription topical: a pea-sized amount of 0.025%-0.1% cream or gel applied to clean, dry skin once nightly. Start low-strength and every-other-night to build tolerance. A prescription drug used under clinician direction — not a supplement regimen.

Before bed

Topical cream or gel, 0.025%-0.1% (prescription)

30mg extract

Morning · with food (preferred)

Standardized extract (0.5% agnuside or 0.6% aucubin)

• Pregnancy and planning pregnancy (topical retinoid — avoid)
• Breastfeeding (avoid application near areas of infant contact)
• Eczema / rosacea-prone or broken/sunburned skin (irritation)

• Benzoyl peroxide
• Other topical exfoliants (AHAs / BHAs, abrasives)
• Photosensitizing drugs

• Pregnancy (discontinue when pregnant)
• Hormone-sensitive conditions (breast cancer, etc.)
• IVF or fertility treatments (may interfere)

• Hormonal contraceptives
• Dopamine agonists/antagonists
• Hormone replacement therapy