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Evening Primrose Oil (GLA)
Rich source of gamma-linolenic acid (GLA) that supports women's hormonal health, skin conditions, and inflammation.
What the evidence says
Most Evening Primrose Oil studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2007–2025 with a typical study size of 400 participants.
Based on 15 studies · 6 meta-analyses · 3 RCTs · 3,813 total participants
Confidence
HighWhat the studies found
By outcome
See full supplement plans that include Evening Primrose Oil.
Evening Primrose Oil has an evidence score of 7.5/10 — strong evidence based on 15 indexed studies, including 13 meta-analyses. Rich source of gamma-linolenic acid (GLA) that supports women's hormonal health, skin conditions, and inflammation.
The commonly studied dose of Evening Primrose Oil is 1000-3000mg (providing 80-240mg GLA). Research points to an estimated optimal dose around 2500mg, with a minimum effective dose near 1000mg. Individual response varies — start low and adjust.
The best time to take Evening Primrose Oil is with meals. Take it with food. Evening primrose oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid.
Soy Isoflavones
Likely helpsPlant compounds with weak estrogenic effects that support menopausal symptoms, bone health, and cardiovascular function.
Indole-3-Carbinol
Likely helpsConverts to DIM in the stomach, shifting estrogen metabolism toward favorable 2-hydroxy metabolites for hormonal balance.
Last reviewed May 2026 · evidence from 40 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Evening Primrose Oil is extracted from the seeds of the evening primrose plant and is one of the richest sources of gamma-linolenic acid (GLA), an omega-6 fatty acid. Unlike most omega-6s, GLA has anti-inflammatory effects. Research supports benefits for PMS, breast pain, eczema, and hormonal balance. A staple in women's health.
GLA converts to anti-inflammatory prostaglandins
Supports healthy skin lipid composition
How Evening Primrose Oil works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
1000-3000mg (providing 80-240mg GLA)
Take with food
| Form | Type |
|---|---|
| 💊Softgels (cold-pressed oil) | Recommended |
| 💧Liquid oil | Alternative |
Look for cold-pressed oil. Keep refrigerated to prevent rancidity. Check GLA content.
Minimum: 8 weeks
Optimal: 12 weeks
Cycling: Not required
Note: Take with food containing fat for best absorption. Can split into 2-3 doses.
Based on meta-analysis of oral evening primrose oil for eczema (n=1596). Effect size is conservative given mixed quality of studies and modest clinical improvements typically seen.
Less cyclical breast pain
Reduced PMS symptoms
Better skin hydration and eczema symptoms
Sometimes used near term to ripen cervix; consult doctor
Avoid or use with caution
May have mild antiplatelet effects — may affect platelet aggregation or vitamin K-dependent clotting factors, altering anticoagulant efficacy
May lower seizure threshold
May increase seizure risk
Tip: Take with food
Tip: Usually resolves
Tip: Reduce dose
Evening Primrose Oil is generally well-tolerated and considered safe for most healthy adults at recommended doses. The most commonly reported side effects are GI upset, headache, soft stools. Use caution if any of these apply to you: Seizure disorders (may lower seizure threshold); Before surgery (stop 2 weeks prior).
Omega-3
Probably helpsEssential fatty acids critical for brain health, mood regulation, and reducing inflammation throughout the body.
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