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SAMe und St. John's Wort können wechselwirken. Additive serotonergic load, and with it a risk of serotonin syndrome. This specific pair has not been studied; St John's wort is a named precipitant of serotonin syndrome in the clinical literature and the same table already grades it critical against every SSRI, SNRI and MAOI. Do not stack them. Two herbal or nutraceutical antidepressants together is not a stronger treatment, it is an untested one — pick one and give it a fair trial. Seek urgent medical help for agitation, shivering, twitching, a racing heart, sweating or fever.
Additive serotonergic load, and with it a risk of serotonin syndrome. This specific pair has not been studied; St John's wort is a named precipitant of serotonin syndrome in the clinical literature and the same table already grades it critical against every SSRI, SNRI and MAOI.
Both are taken AS antidepressants and both act on monoamine signalling — St John's wort through reuptake inhibition across serotonin, noradrenaline and dopamine, SAMe through methylation-dependent monoamine turnover and 5-HT1A activation.
Was zu tun ist: Do not stack them. Two herbal or nutraceutical antidepressants together is not a stronger treatment, it is an untested one — pick one and give it a fair trial. Seek urgent medical help for agitation, shivering, twitching, a racing heart, sweating or fever.
This information is for educational purposes only. Sie ersetzt keine professionelle medizinische Beratung. Sprich immer mit einer qualifizierten medizinischen Fachperson, bevor du ein Supplement oder Medikament beginnst, absetzt oder änderst.