5-HTP and SAMe: Can You Take Them Together?

Häufig gestellte Fragen

Kann man 5-HTP und SAMe zusammen einnehmen?

5-HTP und SAMe können wechselwirken. Additive serotonergic load, and with it a risk of serotonin syndrome: agitation, shivering, tremor, twitching muscles, sweating, a fast heartbeat and, at the severe end, fever and rigidity. This specific pair has not been studied; the risk is inferred from what each does alone and from how the same table already grades each against prescription serotonergics. Do not stack them. If both are being considered for mood, pick one and give it a fair trial. Seek urgent medical help for agitation, shivering, twitching, a racing heart, sweating or fever. Anyone already on an antidepressant should not be taking either without their prescriber.

Wechselwirken 5-HTP und SAMe?

Additive serotonergic load, and with it a risk of serotonin syndrome: agitation, shivering, tremor, twitching muscles, sweating, a fast heartbeat and, at the severe end, fever and rigidity. This specific pair has not been studied; the risk is inferred from what each does alone and from how the same table already grades each against prescription serotonergics. 5-HTP is the immediate precursor of serotonin and raises its synthesis directly. SAMe raises monoamine turnover and acts at 5-HT1A receptors — the mechanism behind its antidepressant effect. Both push the same system.

Sollte man 5-HTP und SAMe zeitlich trennen?

Do not stack them. If both are being considered for mood, pick one and give it a fair trial. Seek urgent medical help for agitation, shivering, twitching, a racing heart, sweating or fever. Anyone already on an antidepressant should not be taking either without their prescriber.