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Migraine Prevention Stack
The supplement combination with the most neurology support for migraine prevention.
Your stack addresses some goals but has significant gaps.
What's in this stack
- Magnesium8.5/10 evidence
Supports 300+ enzymatic reactions — critical for sleep, stress response, muscle function, and cognitive health.
Typical dose: 200-250mg elemental magnesium daily
- Riboflavin6.5/10 evidence
Component of FAD/FMN coenzymes for energy production — studied at high dose (400mg) for headache frequency.
Typical dose: 25-50mg for general health; 400mg for migraine prevention (the one cited trial used 400 mg, none used 25 to 50 mg)
- CoQ108/10 evidence
A lipid-soluble antioxidant central to mitochondrial energy production, with the strongest trial support for fertility/IVF outcomes and heart failure.
Typical dose: 100-300mg daily
- Feverfew5/10 evidence
A traditional migraine-prevention herb with mixed, inconsistent trial evidence — some older RCTs were positive, but the pivotal standardized-extract trial missed its primary endpoint.
Typical dose: 18.75-56.25 mg daily of a standardized CO2 extract (the cited trial gave 6.24, 18.75 or 56.25 mg a day in three doses, found no effect overall, and only a subgroup on 18.75 mg a day had fewer attacks). Leaf and extract products are labelled at 100-300 mg daily, standardized to at least 0.2-0.7% parthenolide, above the highest dose in the cited trial.
What this stack covers
- Support heart health64% · via CoQ10
- Speed up recovery68% · via Magnesium
- Metabolic health0%
- Metabolic healthgap — not covered
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