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Evidenzbasierte Nahrungsergänzungsmittel ähnlich wie Pioglitazone (Actos), sortiert nach gemeinsamen Zielen und klinischer Evidenz. Vergleiche unten beliebige davon direkt miteinander.
An SGLT2-inhibitor diabetes drug (Invokana) that lowers glucose by excreting it in urine. It extended lifespan in male mice in the NIA aging program, and the SGLT2 class has strong proven cardiovascular, kidney, and heart-failure benefits in humans. Longevity benefit itself is unproven; carries genital-infection and (rarely) ketoacidosis risks. Prescription drug, not a supplement.
An SGLT2-inhibitor diabetes drug (Jardiance) with the strongest human outcome evidence of its class — it cuts cardiovascular death, heart-failure hospitalization, and kidney-disease progression even in non-diabetics. The most widely used SGLT2 for off-label 'longevity,' though longevity itself is unproven (the lifespan data are for sibling canagliflozin in mice). A prescription drug, not a supplement.
An SGLT2-inhibitor diabetes drug (Farxiga/Forxiga) with broad, robust human outcome evidence — it cuts heart-failure hospitalization and cardiovascular death across the ejection-fraction spectrum and slows kidney-disease progression, including in non-diabetics. The sibling of empagliflozin, used off-label for 'longevity,' though longevity itself is unproven (the lifespan data are for sibling canagliflozin in mice). A prescription drug, not a supplement.
An oral diabetes drug (alpha-glucosidase inhibitor) that blunts post-meal glucose spikes. It robustly extended lifespan in male mice in the NIA aging program and reduced cardiovascular events in human prevention trials. Human longevity benefit is unproven; the main downside is gas/GI side effects. A prescription drug taken off-label, not a supplement.
A first-line type-2-diabetes drug (Glucophage) studied as a geroprotector and the basis of the TAME longevity trial. The human longevity case rests on diabetic-population epidemiology and one large meta-analysis; it is genuinely contested — including evidence it can blunt exercise adaptations. A prescription drug taken off-label, not a supplement.
Activates AMPK to regulate blood sugar, improve insulin sensitivity, and support lipid metabolism — comparable to metformin in some trials.
Universal antioxidant that works in both water and fat, supporting blood sugar control, nerve health, and cellular energy.
A polyphenol-rich spice studied mainly for modest improvements in blood sugar and blood lipids; choose Ceylon to limit coumarin.
This information is for educational purposes only. Sie ersetzt keine professionelle medizinische Beratung. Sprich immer mit einer qualifizierten medizinischen Fachperson, bevor du ein Supplement oder Medikament beginnst, absetzt oder änderst.