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Caffeine and Exogenous Ketones are generally complementary — many people take them together. If you are combining these for performance, expect caffeine to be doing the work. Do not add a ketone ester before a short high-intensity effort.
Caffeine carries the evidence here; ketones are an experimental adjunct whose endurance-performance effect is null on meta-analysis, and ketone ester measurably reduced 30-min time-trial power.
Layered acute support for performance and cognition via unrelated mechanisms.
What to do: If you are combining these for performance, expect caffeine to be doing the work. Do not add a ketone ester before a short high-intensity effort.
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.