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Caffeine and Synephrine can interact. Possible added cardiovascular stimulation (heart rate, blood pressure). French (ANSES 2014) and German (BfR 2012) risk assessments advise against combining synephrine with caffeine, as the cardiovascular effects may reinforce each other. The size of the risk is not established, and the one cited 8-week trial, which gave a caffeine-containing product with and without synephrine, found no increase in side effects or resting heart rate. AVOID combination. Monitor cardiovascular status if used together.
Possible added cardiovascular stimulation (heart rate, blood pressure). French (ANSES 2014) and German (BfR 2012) risk assessments advise against combining synephrine with caffeine, as the cardiovascular effects may reinforce each other. The size of the risk is not established, and the one cited 8-week trial, which gave a caffeine-containing product with and without synephrine, found no increase in side effects or resting heart rate.
Both stimulate the sympathetic nervous system, and synephrine is adrenergic, so additive stimulation is plausible
What to do: AVOID combination. Monitor cardiovascular status if used together.
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.