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Calcium and Magnesium have at most a minor documented interaction. No separation and no fixed ratio are needed at usual doses. While a diagnosed magnesium deficiency is being treated, taking them at different times is a reasonable precaution.
In two randomised trials in adolescent girls, about 1,000 mg of extra calcium a day did not change magnesium absorption or balance. No harm from taking them together has been shown, and no trial defines an optimal calcium to magnesium ratio for adults.
Calcium and magnesium share intestinal absorption routes, and studies of their interaction are inconsistent
What to do: No separation and no fixed ratio are needed at usual doses. While a diagnosed magnesium deficiency is being treated, taking them at different times is a reasonable precaution.
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.