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Calcium and Omega-3 can be taken together. Any benefit from combining them rests on limited evidence. Omega-3 (1–3 g EPA+DHA/day) can be taken with calcium. A bone benefit of omega-3 alone has not been shown. Take with calcium-containing meals as the fat content enhances absorption of both nutrients.
In a small pilot RCT of 65 elderly women who all took calcium, spine bone density stayed stable and hip bone density rose on GLA plus EPA, while both fell on placebo. It tested GLA together with EPA, not omega-3 alone.
Omega-3 fatty acids (EPA/DHA) enhance calcium absorption by increasing intestinal membrane fluidity, facilitating calcium transport through enterocyte membranes. EPA and DHA also reduce urinary calcium excretion by modulating renal prostaglandin E2 levels. Additionally, omega-3s suppress NF-κB mediated osteoclastogenesis and promote osteoblast differentiation, complementing calcium's bone mineralization effects.
What to do: Omega-3 (1–3 g EPA+DHA/day) can be taken with calcium. A bone benefit of omega-3 alone has not been shown. Take with calcium-containing meals as the fat content enhances absorption of both nutrients.
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.