Orlistat and Vitamin D3: Can You Take Them Together?

Notable interaction — adjust timing

Orlistat and Vitamin D3 can interact. Lower vitamin D absorption, with measurable falls in fat-soluble vitamin concentrations reported during orlistat treatment. Orlistat can reduce vitamin D absorption. Ask your prescriber or pharmacist to confirm your vitamin D or multivitamin plan. When taking a vitamin supplement with US Xenical, separate it by at least two hours before or after an orlistat dose. Follow any monitoring advice.

What the evidence says

moderateconflict· moderate evidence

Lower vitamin D absorption, with measurable falls in fat-soluble vitamin concentrations reported during orlistat treatment.

Orlistat inhibits gastric and pancreatic lipase, so dietary fat passes unabsorbed — and fat-soluble vitamins absorbed with it are reduced in parallel.

What to do: Orlistat can reduce vitamin D absorption. Ask your prescriber or pharmacist to confirm your vitamin D or multivitamin plan. When taking a vitamin supplement with US Xenical, separate it by at least two hours before or after an orlistat dose. Follow any monitoring advice.

Orlistat

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Vitamin D3

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Compare Orlistat vs Vitamin D3 Check your full stack

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Frequently asked questions

Can you take Orlistat and Vitamin D3 together?: Orlistat and Vitamin D3 can interact. Lower vitamin D absorption, with measurable falls in fat-soluble vitamin concentrations reported during orlistat treatment. Orlistat can reduce vitamin D absorption. Ask your prescriber or pharmacist to confirm your vitamin D or multivitamin plan. When taking a vitamin supplement with US Xenical, separate it by at least two hours before or after an orlistat dose. Follow any monitoring advice.
Do Orlistat and Vitamin D3 interact?: Lower vitamin D absorption, with measurable falls in fat-soluble vitamin concentrations reported during orlistat treatment. Orlistat inhibits gastric and pancreatic lipase, so dietary fat passes unabsorbed — and fat-soluble vitamins absorbed with it are reduced in parallel.
Should you separate Orlistat and Vitamin D3?: Orlistat can reduce vitamin D absorption. Ask your prescriber or pharmacist to confirm your vitamin D or multivitamin plan. When taking a vitamin supplement with US Xenical, separate it by at least two hours before or after an orlistat dose. Follow any monitoring advice.

This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.

What the evidence says

moderateconflict· moderate evidence

Lower vitamin D absorption, with measurable falls in fat-soluble vitamin concentrations reported during orlistat treatment.

Orlistat inhibits gastric and pancreatic lipase, so dietary fat passes unabsorbed — and fat-soluble vitamins absorbed with it are reduced in parallel.

Frequently asked questions

Can you take Orlistat and Vitamin D3 together?

Do Orlistat and Vitamin D3 interact?

Lower vitamin D absorption, with measurable falls in fat-soluble vitamin concentrations reported during orlistat treatment. Orlistat inhibits gastric and pancreatic lipase, so dietary fat passes unabsorbed — and fat-soluble vitamins absorbed with it are reduced in parallel.

Should you separate Orlistat and Vitamin D3?

Orlistat can reduce vitamin D absorption. Ask your prescriber or pharmacist to confirm your vitamin D or multivitamin plan. When taking a vitamin supplement with US Xenical, separate it by at least two hours before or after an orlistat dose. Follow any monitoring advice.