Orlistat and Vitamin D3: Can You Take Them Together?

Notable interaction — adjust timing

Orlistat and Vitamin D3 can interact. Lower vitamin D absorption, with measurable falls in fat-soluble vitamin concentrations reported during orlistat treatment. Keep taking vitamin D, but separate it from any orlistat dose by at least two hours — bedtime is the usual advice, since orlistat is taken with meals.

What the evidence says

moderateconflict· moderate evidence

Lower vitamin D absorption, with measurable falls in fat-soluble vitamin concentrations reported during orlistat treatment.

Orlistat inhibits gastric and pancreatic lipase, so dietary fat passes unabsorbed — and fat-soluble vitamins absorbed with it are reduced in parallel.

What to do: Keep taking vitamin D, but separate it from any orlistat dose by at least two hours — bedtime is the usual advice, since orlistat is taken with meals.

Orlistat

Evidence, dosage & safety →

Vitamin D3

Evidence, dosage & safety →

Compare Orlistat vs Vitamin D3 Check your full stack

Related interactions

Orlistat & Vitamin E Orlistat & Vitamin K2 Multivitamin & Orlistat Calcium & Vitamin D3 Vitamin D3 & Vitamin K2 Magnesium & Vitamin D3

Frequently asked questions

Can you take Orlistat and Vitamin D3 together?: Orlistat and Vitamin D3 can interact. Lower vitamin D absorption, with measurable falls in fat-soluble vitamin concentrations reported during orlistat treatment. Keep taking vitamin D, but separate it from any orlistat dose by at least two hours — bedtime is the usual advice, since orlistat is taken with meals.
Do Orlistat and Vitamin D3 interact?: Lower vitamin D absorption, with measurable falls in fat-soluble vitamin concentrations reported during orlistat treatment. Orlistat inhibits gastric and pancreatic lipase, so dietary fat passes unabsorbed — and fat-soluble vitamins absorbed with it are reduced in parallel.
Should you separate Orlistat and Vitamin D3?: Keep taking vitamin D, but separate it from any orlistat dose by at least two hours — bedtime is the usual advice, since orlistat is taken with meals.

This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.

What the evidence says

moderateconflict· moderate evidence

Lower vitamin D absorption, with measurable falls in fat-soluble vitamin concentrations reported during orlistat treatment.

Orlistat inhibits gastric and pancreatic lipase, so dietary fat passes unabsorbed — and fat-soluble vitamins absorbed with it are reduced in parallel.

What to do: Keep taking vitamin D, but separate it from any orlistat dose by at least two hours — bedtime is the usual advice, since orlistat is taken with meals.

Frequently asked questions

Can you take Orlistat and Vitamin D3 together?

Do Orlistat and Vitamin D3 interact?

Lower vitamin D absorption, with measurable falls in fat-soluble vitamin concentrations reported during orlistat treatment. Orlistat inhibits gastric and pancreatic lipase, so dietary fat passes unabsorbed — and fat-soluble vitamins absorbed with it are reduced in parallel.

Should you separate Orlistat and Vitamin D3?

Keep taking vitamin D, but separate it from any orlistat dose by at least two hours — bedtime is the usual advice, since orlistat is taken with meals.