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Orlistat and Vitamin K2 can interact. Reduced vitamin K absorption. In anyone taking warfarin this can destabilise INR — a case report describes orlistat enhancing warfarin effect. Separate by at least two hours. If you take warfarin, do not start or stop orlistat without INR monitoring.
Reduced vitamin K absorption. In anyone taking warfarin this can destabilise INR — a case report describes orlistat enhancing warfarin effect.
Vitamin K is fat-soluble; orlistat reduces its absorption. This matters beyond nutrition because vitamin K status governs warfarin response.
What to do: Separate by at least two hours. If you take warfarin, do not start or stop orlistat without INR monitoring.
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.