Vitamin D3 and Vitamin K2: Can You Take Them Together?

Possible benefit, limited evidence

Vitamin D3 and Vitamin K2 can be taken together. Any benefit from combining them rests on limited evidence. Optional. They can be taken together and there may be a small benefit, but the evidence is limited and K2 is not needed for vitamin D to work. Anyone on warfarin or another vitamin K antagonist should not start K2 without their prescriber.

What the evidence says

possible benefitsynergy· limited evidence

A 2020 meta-analysis of 8 trials found vitamin K plus vitamin D slightly raised total bone density and lowered undercarboxylated osteocalcin. The trials used different vitamin K forms and doses, one of them high-dose MK-4 with alfacalcidol, an active vitamin D drug, so they are not direct evidence for ordinary vitamin D3 with a consumer dose of MK-7. No trial has shown that adding K2 to vitamin D prevents arterial calcification.

Vitamin D raises calcium absorption and osteocalcin production. K2 is the cofactor that carboxylates osteocalcin and matrix Gla protein

What to do: Optional. They can be taken together and there may be a small benefit, but the evidence is limited and K2 is not needed for vitamin D to work. Anyone on warfarin or another vitamin K antagonist should not start K2 without their prescriber.

Vitamin D3

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Vitamin K2

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Compare Vitamin D3 vs Vitamin K2 Check your full stack

Related interactions

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Frequently asked questions

Can you take Vitamin D3 and Vitamin K2 together?: Vitamin D3 and Vitamin K2 can be taken together. Any benefit from combining them rests on limited evidence. Optional. They can be taken together and there may be a small benefit, but the evidence is limited and K2 is not needed for vitamin D to work. Anyone on warfarin or another vitamin K antagonist should not start K2 without their prescriber.
Do Vitamin D3 and Vitamin K2 interact?: A 2020 meta-analysis of 8 trials found vitamin K plus vitamin D slightly raised total bone density and lowered undercarboxylated osteocalcin. The trials used different vitamin K forms and doses, one of them high-dose MK-4 with alfacalcidol, an active vitamin D drug, so they are not direct evidence for ordinary vitamin D3 with a consumer dose of MK-7. No trial has shown that adding K2 to vitamin D prevents arterial calcification. Vitamin D raises calcium absorption and osteocalcin production. K2 is the cofactor that carboxylates osteocalcin and matrix Gla protein
Should you separate Vitamin D3 and Vitamin K2?: Optional. They can be taken together and there may be a small benefit, but the evidence is limited and K2 is not needed for vitamin D to work. Anyone on warfarin or another vitamin K antagonist should not start K2 without their prescriber.

This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.

What the evidence says

possible benefitsynergy· limited evidence

Vitamin D raises calcium absorption and osteocalcin production. K2 is the cofactor that carboxylates osteocalcin and matrix Gla protein

Frequently asked questions

Can you take Vitamin D3 and Vitamin K2 together?

Do Vitamin D3 and Vitamin K2 interact?

Should you separate Vitamin D3 and Vitamin K2?

Optional. They can be taken together and there may be a small benefit, but the evidence is limited and K2 is not needed for vitamin D to work. Anyone on warfarin or another vitamin K antagonist should not start K2 without their prescriber.