Synephrine and Yohimbine: Can You Take Them Together?

Use caution — significant interaction

Synephrine and Yohimbine can interact. Raised blood pressure and heart rate, palpitations, chest pain, anxiety and insomnia. Case reports of arrhythmia, hypertensive events and ischaemia in users of multi-ingredient stimulant supplements repeatedly involve exactly this kind of combination, and yohimbine content in such products is frequently mislabelled. Do not combine, and check the label of any pre-workout or fat-burner before adding either — many already contain both, plus caffeine. Anyone with high blood pressure, an arrhythmia, an anxiety disorder or heart disease should avoid both individually.

What the evidence says

majorconflict· moderate evidence

p-Synephrine is an adrenergic agonist that raises heart rate and blood pressure directly. Yohimbine blocks presynaptic alpha-2 adrenoceptors, which removes the brake on noradrenaline release. One adds agonist, the other removes the negative feedback — the effects compound rather than simply add.

What to do: Do not combine, and check the label of any pre-workout or fat-burner before adding either — many already contain both, plus caffeine. Anyone with high blood pressure, an arrhythmia, an anxiety disorder or heart disease should avoid both individually.

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Frequently asked questions

Can you take Synephrine and Yohimbine together?: Synephrine and Yohimbine can interact. Raised blood pressure and heart rate, palpitations, chest pain, anxiety and insomnia. Case reports of arrhythmia, hypertensive events and ischaemia in users of multi-ingredient stimulant supplements repeatedly involve exactly this kind of combination, and yohimbine content in such products is frequently mislabelled. Do not combine, and check the label of any pre-workout or fat-burner before adding either — many already contain both, plus caffeine. Anyone with high blood pressure, an arrhythmia, an anxiety disorder or heart disease should avoid both individually.
Do Synephrine and Yohimbine interact?: Raised blood pressure and heart rate, palpitations, chest pain, anxiety and insomnia. Case reports of arrhythmia, hypertensive events and ischaemia in users of multi-ingredient stimulant supplements repeatedly involve exactly this kind of combination, and yohimbine content in such products is frequently mislabelled. p-Synephrine is an adrenergic agonist that raises heart rate and blood pressure directly. Yohimbine blocks presynaptic alpha-2 adrenoceptors, which removes the brake on noradrenaline release. One adds agonist, the other removes the negative feedback — the effects compound rather than simply add.
Should you separate Synephrine and Yohimbine?: Do not combine, and check the label of any pre-workout or fat-burner before adding either — many already contain both, plus caffeine. Anyone with high blood pressure, an arrhythmia, an anxiety disorder or heart disease should avoid both individually.

This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.

What the evidence says

majorconflict· moderate evidence

Frequently asked questions

Can you take Synephrine and Yohimbine together?

Do Synephrine and Yohimbine interact?

Raised blood pressure and heart rate, palpitations, chest pain, anxiety and insomnia. Case reports of arrhythmia, hypertensive events and ischaemia in users of multi-ingredient stimulant supplements repeatedly involve exactly this kind of combination, and yohimbine content in such products is frequently mislabelled. p-Synephrine is an adrenergic agonist that raises heart rate and blood pressure directly. Yohimbine blocks presynaptic alpha-2 adrenoceptors, which removes the brake on noradrenaline release. One adds agonist, the other removes the negative feedback — the effects compound rather than simply add.

Should you separate Synephrine and Yohimbine?

Do not combine, and check the label of any pre-workout or fat-burner before adding either — many already contain both, plus caffeine. Anyone with high blood pressure, an arrhythmia, an anxiety disorder or heart disease should avoid both individually.