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Head-to-head evidence comparison — which supplement is right for you?
Synephrine vs Yohimbine: Yohimbine has the stronger overall evidence (5 vs 4.8/10); they're alternatives for manage weight — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Yohimbine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Too few graded studies
Top outcomes
Shared outcomes (2)
Outcomes where both Synephrine and Yohimbine have evidence — compare verdict strength side-by-side.
10-20mg p-synephrine 1-2x daily (≤50mg/day); avoid or minimize combining with caffeine/other stimulants (a typical label dose, not the dose used in the cited trials, which used 3 mg per kg of body weight)
Morning
Standardized p-synephrine (stated dose)
Standardized yohimbine HCl ~0.2 mg/kg (roughly 5-15 mg) up to 1-2x daily; start at the lowest dose, ideally fasted for the fat-loss effect. Never combine with other stimulants.
Morning
Standardized yohimbine HCl (known dose)
and 1 more not shown
and 2 more not shown
Potential interaction under clinical review.
Not graded yet, under clinical review. Precaution meanwhile: Avoid combining stimulant supplements with another stimulant without prescriber advice. Seek emergency help for chest pain, collapse or severe breathlessness. Do not reduce or stop a prescribed stimulant to accommodate a supplement.
Acute
Acute
Acute
Throughout use
3-8 weeks
2-8 weeks
Acute
Acute
The Safety and Efficacy of Citrus aurantium (Bitter Orange) Extracts and p-Synephrine: A Systematic Review and Meta-Analysis.
Nutrients (2022) · Meta analysis
Both systolic and diastolic blood pressure increased significantly after prolonged use (SBP 6.37 mmHg, P = 0.02; DBP 4.33 mmHg, P = 0.03)
Safety and efficacy of citrus aurantium for weight loss.
The American journal of cardiology (2004) · Systematic review
Only 1 eligible RCT identified (20 patients, 6 weeks)
An evidence-based systematic review of bitter orange (Citrus aurantium) by the Natural Standard Research Collaboration.
Journal of dietary supplements (2013) · Systematic review
The review covers clinical trials, pharmacology, interactions, adverse effects, toxicology and dosing of bitter orange.
Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials.
The Journal of urology (1998) · Meta analysis
Meta-analysis of seven placebo-controlled RCTs of yohimbine monotherapy for erectile dysfunction
Yohimbine as a treatment for erectile dysfunction: A systematic review and meta-analysis.
Turkish journal of urology (2021) · Meta analysis
Systematic review and meta-analysis of eight RCTs comparing yohimbine with placebo or no treatment for erectile dysfunction.
Yohimbine: the effects on body composition and exercise performance in soccer players.
Research in sports medicine (2006) · Rct · n=20
Randomized placebo-controlled trial in 20 elite male soccer players, 20 mg/day for 21 days
Yohimbine has a higher evidence score (5/10 vs 4.8/10) and wins in 2 of 3 categories.
For manage weight, Yohimbine has a higher relevance score (55 vs 48).
Not graded yet, under clinical review. Precaution meanwhile: Avoid combining stimulant supplements with another stimulant without prescriber advice. Seek emergency help for chest pain, collapse or severe breathlessness. Do not reduce or stop a prescribed stimulant to accommodate a supplement.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.