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Head-to-head evidence comparison — which supplement is right for you?
Synephrine vs Yohimbine: Yohimbine has the stronger overall evidence (5 vs 4.8/10); take care combining them — there's a flagged interaction. Take the 60-second quiz for a pick tailored to your goals.
Yohimbine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (1)
Outcomes where both Synephrine and Yohimbine have evidence — compare verdict strength side-by-side.
10-20mg p-synephrine 1-2x daily (≤50mg/day); avoid or minimize combining with caffeine/other stimulants
morning
Standardized p-synephrine (stated dose)
Standardized yohimbine HCl ~0.2 mg/kg (roughly 5-15 mg) up to 1-2x daily; start at the lowest dose, ideally fasted for the fat-loss effect. Never combine with other stimulants.
morning
Standardized yohimbine HCl (known dose)
and 1 more not shown
and 2 more not shown
Raised blood pressure and heart rate, palpitations, chest pain, anxiety and insomnia. Case reports of arrhythmia, hypertensive events and ischaemia in users of multi-ingredient stimulant supplements repeatedly involve exactly this kind of combination, and yohimbine content in such products is frequently mislabelled.
Do not combine, and check the label of any pre-workout or fat-burner before adding either — many already contain both, plus caffeine. Anyone with high blood pressure, an arrhythmia, an anxiety disorder or heart disease should avoid both individually.
Acute
Acute
Acute
Throughout use
3-8 weeks
2-8 weeks
Acute
Acute
The Safety and Efficacy of Citrus aurantium (Bitter Orange) Extracts and p-Synephrine: A Systematic Review and Meta-Analysis.
Nutrients (2022) · Meta analysis
Both systolic and diastolic blood pressure increased significantly after prolonged use (SBP 6.37 mmHg, P = 0.02; DBP 4.33 mmHg, P = 0.03)
Safety and efficacy of citrus aurantium for weight loss.
The American journal of cardiology (2004) · Systematic review
Only 1 eligible RCT identified (20 patients, 6 weeks)
An evidence-based systematic review of bitter orange (Citrus aurantium) by the Natural Standard Research Collaboration.
Journal of dietary supplements (2013) · Systematic review
Modest thermogenic/metabolic effects
Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials.
The Journal of urology (1998) · Meta analysis
Meta-analysis of seven placebo-controlled RCTs of yohimbine monotherapy for erectile dysfunction
Yohimbine as a treatment for erectile dysfunction: A systematic review and meta-analysis.
Turkish journal of urology (2021) · Meta analysis
Systematic review and meta-analysis of eight RCTs comparing yohimbine to placebo for ED
Yohimbine: the effects on body composition and exercise performance in soccer players.
Research in sports medicine (2006) · Rct · n=20
Randomized placebo-controlled trial in 20 elite male soccer players, 20 mg/day for 21 days
Yohimbine has a higher evidence score (5/10 vs 4.8/10) and wins in 2 of 3 categories.
For manage weight, Yohimbine has a higher relevance score (55 vs 48).
Caution: Raised blood pressure and heart rate, palpitations, chest pain, anxiety and insomnia. Case reports of arrhythmia, hypertensive events and ischaemia in users of multi-ingredient stimulant supplements repeatedly involve exactly this kind of combination, and yohimbine content in such products is frequently mislabelled. Do not combine, and check the label of any pre-workout or fat-burner before adding either — many already contain both, plus caffeine. Anyone with high blood pressure, an arrhythmia, an anxiety disorder or heart disease should avoid both individually. Always consult a healthcare provider before combining these supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.