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Phenylpiracetam (Phenotropil)
30-60x more potent than piracetam — developed for cosmonauts, banned by WADA for its cognitive and physical performance effects.
What the evidence says
Most Phenylpiracetam studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2010–2025 with a typical study size of 549 participants.
Based on 5 studies · 1 meta-analysis · 549 total participants
Confidence
ModerateWhat the studies found
By outcome
Phenylpiracetam has an evidence score of 6/10 — moderate evidence based on 5 indexed studies, including 1 meta-analysis. 30-60x more potent than piracetam — developed for cosmonauts, banned by WADA for its cognitive and physical performance effects.
The commonly studied dose of Phenylpiracetam is 100-200mg as needed. Research points to an estimated optimal dose around 200mg, with a minimum effective dose near 100mg. Individual response varies — start low and adjust.
The best time to take Phenylpiracetam is in the morning. Taking it with food is preferred. Phenylpiracetam (Phenotropil) is a phenyl-substituted piracetam derivative with psychostimulatory, anxiolytic, and nootropic properties.
Last reviewed May 2026 · evidence from 6 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Phenylpiracetam is a modified version of piracetam with a phenyl group attached, making it 30-60 times more potent. Developed in Russia for cosmonauts, it's known for enhancing both cognitive and physical performance, increasing cold tolerance, and providing stimulant-like effects. It's banned by WADA as a performance-enhancing drug. Tolerance develops quickly, so it's best used occasionally.
Affects dopamine and norepinephrine
Enhances glutamatergic transmission
Improves tolerance to cold
How Phenylpiracetam works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
100-200mg as needed
Loading: Not required; acute effects are primary
Can be taken without food
| Form | Type |
|---|---|
| 💊Phenylpiracetam powder or capsules | Recommended |
Very potent - accurate dosing is important. Powder has bitter taste. Capsules are convenient.
Minimum: 1 weeks
Optimal: 4 weeks
Cycling: Use 2-3x per week maximum; tolerance develops quickly with daily use
Note: Strong stimulant - avoid afternoon/evening. Best used 2-3x per week max to prevent tolerance.
Based on meta-analysis (n=549) and systematic review (n=380) showing cognitive improvements in stroke/TBI patients and asthenia reduction. Effects include mental energy, focus, and psychostimulant properties. Rapid tolerance development limits daily use effectiveness.
Strong stimulant-like cognitive boost
Intense focus and mental clarity
Enhanced stamina and endurance
Effects diminish with daily use
BANNED by WADA - do not use if subject to drug testing
Additive stimulant effects; use caution
Tip: Take only in morning; avoid afternoon doses
Tip: Take with choline source
Tip: Reduce dose or frequency
Phenylpiracetam is generally safe at recommended doses, with a few precautions worth noting. The most commonly reported side effects are insomnia, headache, irritability. Use caution if any of these apply to you: Heart conditions; High blood pressure; Anxiety disorders.
Piracetam
Likely helpsFirst-ever nootropic (1972) that improves membrane fluidity and AMPA receptor function — decades of safety data for cognitive enhancement.
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